Malaria is the most important vector-borne disease in Southeast Asia. It is estimated that the region accounts for 30% of the global malaria morbidity and 8% of the global mortality. Malaria epidemiology in this region is characterized by high spatial and temporal heterogeneity in falciparum and vivax malaria incidences, and by the presence of diverse vector species with different vectorial capacities for the parasites. The sympatric occurrence of multiple vector species with distinct bionomics and vectorial capacity complicates our understanding of malaria transmission and hinders malaria control efforts. Currently, pyrethroid insecticide-treated nets and pyrethroid-based indoor residual spray are the primary vector control tools in the region. However, the evolution and spread of insecticide resistance and drug resistance reduce the efficacy of these tools. Therefore, understanding the vectorial system and developing new vector control and resistance monitoring tools are of paramount importance. The overarching objectives of this project are to understand the vectorial system in diverse ecological and epidemiological settings in China, Thailand and least studied Myanmar, and to develop new vector control tools to reduce malaria transmission. To achieve these objectives, we have developed five specific aims: 1) to determine community structure of malaria vectors and the impact of anthropogenic environmental changes on vector community structure;2) to examine the population genetic structure and bionomics of major malaria vector species;3) to develop new olfaction-based tools for control and transmission surveillance of the major malaria vectors;4) to examine the utility of a new formulation of microbial larvicide and entomopathogenic fungi for adult mosquito control;and 5) to determine pyrethroid resistance mechanisms and develop resistance monitoring tools for the major malaria vectors in the region. We anticipate the new knowledge and new tools from this project will greatly contribute to the malaria control program in Southeast Asia.
Vector control is an integral component of malaria control. SE Asia is characterized by the presence of multiple vector species with different distribution, bionomics and vectorial capacity. We will fill the knowledge gaps in vector biology in this region through innovative research on vector community structure, population genetics, insecticide resistance, and development of novel tools for vector surveillance and control.
|Cui, Liwang; Lindner, Scott; Miao, Jun (2015) Translational regulation during stage transitions in malaria parasites. Ann N Y Acad Sci 1342:9-Jan|
|Xu, Tielong; Zhong, Daibin; Tang, Linhua et al. (2014) Anopheles sinensis mosquito insecticide resistance: comparison of three mosquito sample collection and preparation methods and mosquito age in resistance measurements. Parasit Vectors 7:54|
|Yuan, Lili; Hao, Mingming; Wu, Lanou et al. (2014) Refrigeration provides a simple means to synchronize in vitro cultures of Plasmodium falciparum. Exp Parasitol 140:18-23|
|Putaporntip, Chaturong; Miao, Jun; Kuamsab, Napaporn et al. (2014) The Plasmodium vivax merozoite surface protein 3? sequence reveals contrasting parasite populations in southern and northwestern Thailand. PLoS Negl Trop Dis 8:e3336|
|Gupta, Bhavna; Xu, Shuhui; Wang, Zenglei et al. (2014) Plasmodium falciparum multidrug resistance protein 1 (pfmrp1) gene and its association with in vitro drug susceptibility of parasite isolates from north-east Myanmar. J Antimicrob Chemother 69:2110-7|
|Li, Peipei; Zhao, Zhenjun; Wang, Ying et al. (2014) Nested PCR detection of malaria directly using blood filter paper samples from epidemiological surveys. Malar J 13:175|
|Zhou, Guofa; Sun, Ling; Xia, Rongji et al. (2014) Clinical malaria along the China-Myanmar border, Yunnan Province, China, January 2011-August 2012. Emerg Infect Dis 20:675-8|
|Qin, Qian; Li, Yiji; Zhong, Daibin et al. (2014) Insecticide resistance of Anopheles sinensis and An. vagus in Hainan Island, a malaria-endemic area of China. Parasit Vectors 7:92|
|Zhu, Guoding; Zhong, Daibin; Cao, Jun et al. (2014) Transcriptome profiling of pyrethroid resistant and susceptible mosquitoes in the malaria vector, Anopheles sinensis. BMC Genomics 15:448|
|Wang, Zenglei; Liu, Min; Liang, Xiaoying et al. (2014) A flow cytometry-based quantitative drug sensitivity assay for all Plasmodium falciparum gametocyte stages. PLoS One 9:e93825|
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