This ICEMR program endeavors to achieve a better understanding of malaria epidemiology, vector biology, and mechanisms of artemisinin resistance in Southeast Asia so that more effective, targeted malaria control can be achieved through a combination of accurate surveillance of the disease, integrated vector control, and more effective chemotherapy in this region. The involvement of a large number of key investigators from multiple institutions from the U.S., Thailand, and China, and our strategic selection of multiple study sites in China, Myanmar and Thailand require effective administration of the program. To meet this challenge, this administrative core is established to 1) provide administrative support for managing, coordinating, and supervising the research activities of this program;2) provide financial oversight of grant accounting at participating domestic and foreign institutions;and 3) provide effective administrative management of training components of this program. We have developed an administrative structure and procedures for managing and coordinating all research and training activities. This administrative core will facilitate research-related activities of the program, assist in the organization of ICEMR-related meetings, and develop and submit annual progress and financial reports. In addition to the significant dedication of the program director and codirectors in the overall administration, we have also designated in-country coordinators to further enhance daily supervision and coordination of the scientific activities at the study sites. While this core will provide overall financial administration of the program, a centralized financial administration at the endemic countries will be used to provide additional financial oversight. For the training component of this program, this core will provide administrative support for the career development projects and all other training activities within this program. The extensive collaborations and existing research and training projects among the participating institutions provide us the experience and established mechanisms for the successful administration of this program.

Public Health Relevance

This administrative core aims to provide effective administration and coordination of all scientific activities, financial oversight of grant accounting, and management of training activities of this program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089672-04
Application #
8500153
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$220,645
Indirect Cost
$26,206
Name
Pennsylvania State University
Department
Type
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
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Siddiqui, Faiza A; Cabrera, Mynthia; Wang, Meilian et al. (2018) Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance. J Infect Dis 218:434-442
Yang, Henglin; Wang, Jingyan; Liu, Hui et al. (2018) Randomized, Double-Blind, Placebo-Controlled Studies to Assess Safety and Prophylactic Efficacy of Naphthoquine-Azithromycin Combination for Malaria Prophylaxis in Southeast Asia. Antimicrob Agents Chemother 62:
Chaverra-Rodriguez, Duverney; Macias, Vanessa M; Hughes, Grant L et al. (2018) Targeted delivery of CRISPR-Cas9 ribonucleoprotein into arthropod ovaries for heritable germline gene editing. Nat Commun 9:3008
Mbenda, Huguette Gaelle Ngassa; Zeng, Weilin; Bai, Yao et al. (2018) Genetic diversity of the Plasmodium vivax phosphatidylinositol 3-kinase gene in two regions of the China-Myanmar border. Infect Genet Evol 61:45-52
Bai, Yao; Zhang, Jiaqi; Geng, Jinting et al. (2018) Longitudinal surveillance of drug resistance in Plasmodium falciparum isolates from the China-Myanmar border reveals persistent circulation of multidrug resistant parasites. Int J Parasitol Drugs Drug Resist 8:320-328
Zhao, Yan; Zeng, Jie; Zhao, Yonghong et al. (2018) Risk factors for asymptomatic malaria infections from seasonal cross-sectional surveys along the China-Myanmar border. Malar J 17:247
Deng, Zeshuai; Li, Qing; Yi, Haoan et al. (2018) Hemoglobin E protects against acute Plasmodium vivax infections in a Kachin population at the China-Myanmar border. J Infect 77:435-439
Zhong, Daibin; Koepfli, Cristian; Cui, Liwang et al. (2018) Molecular approaches to determine the multiplicity of Plasmodium infections. Malar J 17:172
Zhu, Xiaotong; He, Yang; Liang, Yifan et al. (2017) Tryptophan-rich domains of Plasmodium falciparum SURFIN4.2 and Plasmodium vivax PvSTP2 interact with membrane skeleton of red blood cell. Malar J 16:121

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