The specific remit of the Genomics Core will be to provide access to sophisticated next-generation sequencing and genomics equipment and software, and to well-trained staff, for the successful completion of several sub-projects of the Epidemiology and Pathogenesis and Diagnosis Projects conducted by Pis of the Center for the Study of Complex Malaria in India (CSCMi). Specifically, the Core will be part of the Central Instrumentation Facility of the NIMR in New Delhi, India, and will be reponsible for the following tasks: to install, operate, and maintain next-generafion equipment capable of high-throughput DNA sequencing;to process and sequence the large numbers of samples expected from the study of var gene diversity conducted as part ofthe Epidemiology Project (Project 1);and to sequence 30 P. vivax whole genomes for the Pathogenesis and Diagnosis Project (Project 3). These activities serve the CSCMi's goal of being a mulfidisciplinary research center in India that integrates clinical and field studies with laboratory, molecular, and genomic methods for malaria control and prevenfion, and its objective of building research capacity in India and helping train the next generation of malaria and mosquito vector biologists.

Public Health Relevance

Malaria is a major public health problem in India, the worid's largest democracy and its second most populous country. This Core provides state-of-the-art equipment and trained staff to perform rapid, highvolume DNA sequencing of malaria and host DNA for research projects conducted by the Center for the Study of Complex Malaria in India, which aims to enhance Indian malaria intervenfion and control programs.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
New York
United States
Zip Code
Mohanty, Sanjib; Benjamin, Laura A; Majhi, Megharay et al. (2017) Magnetic Resonance Imaging of Cerebral Malaria Patients Reveals Distinct Pathogenetic Processes in Different Parts of the Brain. mSphere 2:
Waite, Jessica L; Swain, Sunita; Lynch, Penelope A et al. (2017) Increasing the potential for malaria elimination by targeting zoophilic vectors. Sci Rep 7:40551
Thomas, Shalu; Ravishankaran, Sangamithra; Justin, N A Johnson Amala et al. (2017) Resting and feeding preferences of Anopheles stephensi in an urban setting, perennial for malaria. Malar J 16:111
Wassmer, Samuel Crocodile; Grau, Georges Emile Raymond (2017) Severe malaria: what's new on the pathogenesis front? Int J Parasitol 47:145-152
Mooney, Jason Paul; Wassmer, Samuel Crocodile; Hafalla, Julius Clemence (2017) Type I Interferon in Malaria: A Balancing Act. Trends Parasitol 33:257-260
Beck-Johnson, Lindsay M; Nelson, William A; Paaijmans, Krijn P et al. (2017) The importance of temperature fluctuations in understanding mosquito population dynamics and malaria risk. R Soc Open Sci 4:160969
Uplekar, Swapna; Rao, Pavitra Nagesh; Ramanathapuram, Lalitha et al. (2017) Characterizing Antibody Responses to Plasmodium vivax and Plasmodium falciparum Antigens in India Using Genome-Scale Protein Microarrays. PLoS Negl Trop Dis 11:e0005323
Gruszczyk, Jakub; Lim, Nicholas T Y; Arnott, Alicia et al. (2016) Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement. Proc Natl Acad Sci U S A 113:E191-200
Thomas, Shalu; Ravishankaran, Sangamithra; Justin, Johnson A et al. (2016) Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India. Malar J 15:274
Gallego-Delgado, Julio; Basu-Roy, Upal; Ty, Maureen et al. (2016) Angiotensin receptors and ?-catenin regulate brain endothelial integrity in malaria. J Clin Invest 126:4016-4029

Showing the most recent 10 out of 57 publications