Project 1 has the overall theme of studying the immuno-genetic epidemiology of complex malaria in India as part ofthe Center for the Study of Complex Malaria in India. Single-species infections by a malaria parasite, 'successive'(one after another) infections, mixed-species (two or more concurrent) infections, and mixed-genotype infections will be detected during a 5 year longitudinal study at three eco-epidemiologically different field stations in India, and used in four sub-Projects. Sub-Project 1 will investigate the development of natural immunity to malaria in individuals: its association with prior exposure to malaria, parasite species, and parasite genetic diversity. Sub-Project 1 will also study complex mixed-species infections, and the differing ratios of Plasmodium species in infections across geography and time. Sub-Project 2 will determine the genetic diversity ofthe highly variable

Public Health Relevance

Malaria is a huge public health problem in India, the world?s largest democracy and its second most populous nation. Project 1 investigates which parasite and host factors determine level of malaria severity in India, which ranges from asymptomatic (natural immunity) to deadly. Project 1 results will inform the Center for the Study of Complex Malaria in India's goal of enhancing Indian malaria intervention and control programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089676-04
Application #
8508827
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$798,942
Indirect Cost
$130,902
Name
New York University
Department
Type
DUNS #
041968306
City
New York
State
NY
Country
United States
Zip Code
10012
Wassmer, Samuel Crocodile; Grau, Georges Emile Raymond (2016) Platelets as pathogenetic effectors and killer cells in cerebral malaria. Expert Rev Hematol 9:515-7
Gallego-Delgado, Julio; Basu-Roy, Upal; Ty, Maureen et al. (2016) Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria. J Clin Invest 126:4016-4029
Thomas, Shalu; Ravishankaran, Sangamithra; Justin, Johnson A et al. (2016) Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India. Malar J 15:274
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Murdock, C C; Sternberg, E D; Thomas, M B (2016) Malaria transmission potential could be reduced with current and future climate change. Sci Rep 6:27771
Wassmer, Samuel Crocodile; Grau, Georges Emile Raymond (2016) Severe malaria: what's new on the pathogenesis front? Int J Parasitol :
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Fernandez-Arias, Cristina; Rivera-Correa, Juan; Gallego-Delgado, Julio et al. (2016) Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia. Cell Host Microbe 19:194-203

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