The specific remit of the Genomics Core will be to provide access to sophisticated next-generation sequencing and genomics equipment and software, and to well-trained staff, for the successful completion of several sub-projects of the Epidemiology and Pathogenesis and Diagnosis Projects conducted by Pis of the Center for the Study of Complex Malaria in India (CSCMi). Specifically, the Core will be part of the Central Instrumentation Facility of the NIMR in New Delhi, India, and will be reponsible for the following tasks: to install, operate, and maintain next-generafion equipment capable of high-throughput DNA sequencing;to process and sequence the large numbers of samples expected from the study of var gene diversity conducted as part ofthe Epidemiology Project (Project 1);and to sequence 30 P. vivax whole genomes for the Pathogenesis and Diagnosis Project (Project 3). These activities serve the CSCMi's goal of being a mulfidisciplinary research center in India that integrates clinical and field studies with laboratory, molecular, and genomic methods for malaria control and prevenfion, and its objective of building research capacity in India and helping train the next generation of malaria and mosquito vector biologists.

Public Health Relevance

Malaria is a major public health problem in India, the world's largest democracy and its second most populous country. This Core provides state-of-the-art equipment and trained staff to perform rapid, high volume DNA sequencing of malaria and host DNA for research projects conducted by the Center for the Study of Complex Malaria in India, which aims to enhance Indian malaria intervention and control programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089676-05
Application #
8699672
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10016
Wassmer, Samuel Crocodile; Grau, Georges Emile Raymond (2016) Platelets as pathogenetic effectors and killer cells in cerebral malaria. Expert Rev Hematol 9:515-7
Gallego-Delgado, Julio; Basu-Roy, Upal; Ty, Maureen et al. (2016) Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria. J Clin Invest 126:4016-4029
Thomas, Shalu; Ravishankaran, Sangamithra; Justin, Johnson A et al. (2016) Overhead tank is the potential breeding habitat of Anopheles stephensi in an urban transmission setting of Chennai, India. Malar J 15:274
Wassmer, Samuel C; Carlton, Jane M (2016) Glycophorins, Blood Groups, and Protection from Severe Malaria. Trends Parasitol 32:5-7
Murdock, C C; Sternberg, E D; Thomas, M B (2016) Malaria transmission potential could be reduced with current and future climate change. Sci Rep 6:27771
Wassmer, Samuel Crocodile; Grau, Georges Emile Raymond (2016) Severe malaria: what's new on the pathogenesis front? Int J Parasitol :
Gruszczyk, Jakub; Lim, Nicholas T Y; Arnott, Alicia et al. (2016) Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement. Proc Natl Acad Sci U S A 113:E191-200
Sharma, Divya; Lather, Manila; Dykes, Cherry L et al. (2016) Disagreement in genotyping results of drug resistance alleles of the Plasmodium falciparum dihydrofolate reductase (Pfdhfr) gene by allele-specific PCR (ASPCR) assays and Sanger sequencing. Parasitol Res 115:323-8
Sutton, Patrick L; Luo, Zunping; Divis, Paul C S et al. (2016) Characterizing the genetic diversity of the monkey malaria parasite Plasmodium cynomolgi. Infect Genet Evol 40:243-52
Fernandez-Arias, Cristina; Rivera-Correa, Juan; Gallego-Delgado, Julio et al. (2016) Anti-Self Phosphatidylserine Antibodies Recognize Uninfected Erythrocytes Promoting Malarial Anemia. Cell Host Microbe 19:194-203

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