The specific remit of the Genomics Core will be to provide access to sophisticated next-generation sequencing and genomics equipment and software, and to well-trained staff, for the successful completion of several sub-projects of the Epidemiology and Pathogenesis and Diagnosis Projects conducted by Pis of the Center for the Study of Complex Malaria in India (CSCMi). Specifically, the Core will be part of the Central Instrumentation Facility of the NIMR in New Delhi, India, and will be reponsible for the following tasks: to install, operate, and maintain next-generafion equipment capable of high-throughput DNA sequencing;to process and sequence the large numbers of samples expected from the study of var gene diversity conducted as part ofthe Epidemiology Project (Project 1);and to sequence 30 P. vivax whole genomes for the Pathogenesis and Diagnosis Project (Project 3). These activities serve the CSCMi's goal of being a mulfidisciplinary research center in India that integrates clinical and field studies with laboratory, molecular, and genomic methods for malaria control and prevenfion, and its objective of building research capacity in India and helping train the next generation of malaria and mosquito vector biologists.

Public Health Relevance

Malaria is a major public health problem in India, the world's largest democracy and its second most populous country. This Core provides state-of-the-art equipment and trained staff to perform rapid, high volume DNA sequencing of malaria and host DNA for research projects conducted by the Center for the Study of Complex Malaria in India, which aims to enhance Indian malaria intervention and control programs.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
New York
United States
Zip Code
Hupalo, Daniel N; Bradic, Martina; Carlton, Jane M (2015) The impact of genomics on population genetics of parasitic diseases. Curr Opin Microbiol 23:49-54
Cator, Lauren J; Lynch, Penelope A; Thomas, Matthew B et al. (2014) Alterations in mosquito behaviour by malaria parasites: potential impact on force of infection. Malar J 13:164
Kar, Narayani Prasad; Kumar, Ashwani; Singh, Om P et al. (2014) A review of malaria transmission dynamics in forest ecosystems. Parasit Vectors 7:265
Cator, Lauren J; Thomas, Shalu; Paaijmans, Krijn P et al. (2013) Characterizing microclimate in urban malaria transmission settings: a case study from Chennai, India. Malar J 12:84
Mideo, Nicole; Kennedy, David A; Carlton, Jane M et al. (2013) Ahead of the curve: next generation estimators of drug resistance in malaria infections. Trends Parasitol 29:321-8
Paaijmans, Krijn P; Cator, Lauren J; Thomas, Matthew B (2013) Temperature-dependent pre-bloodmeal period and temperature-driven asynchrony between parasite development and mosquito biting rate reduce malaria transmission intensity. PLoS One 8:e55777
Cator, Lauren J; George, Justin; Blanford, Simon et al. (2013) 'Manipulation' without the parasite: altered feeding behaviour of mosquitoes is not dependent on infection with malaria parasites. Proc Biol Sci 280:20130711
Carlton, Jane M; Das, Aparup; Escalante, Ananias A (2013) Genomics, population genetics and evolutionary history of Plasmodium vivax. Adv Parasitol 81:203-22
Laishram, Dolie D; Sutton, Patrick L; Nanda, Nutan et al. (2012) The complexities of malaria disease manifestations with a focus on asymptomatic malaria. Malar J 11:29
Das, Aparup; Anvikar, Anupkumar R; Cator, Lauren J et al. (2012) Malaria in India: the center for the study of complex malaria in India. Acta Trop 121:267-73

Showing the most recent 10 out of 13 publications