The long-term project goal is to provide the evidence-base for the development of sustainable strategies to further reduce malaria transmission in southern Africa and assess the feasibility of malaria elimination through an integrated understanding of local malaria epidemiology, vector biology, parasite population structure and community and household-level beliefs and actions. Building upon the Johns Hopkins Malaria Research Institute field site in Choma District in rural southern Zambia as a regional center of excellence in malaria research, we propose to investigate the changing epidemiology of malaria in three distinct transmission settings in southern Africa reflecting different stages of malaria control (successful - Choma, ineffective - Nchelenge, resurgent - Mutasa) through prospective hospital, clinic and community-based studies to address the following:
Aim 1) Measure changes in spatio-temporal patterns of malaria parasitemia in three distinct epidemiological settings in southern Africa and identify individual, household and ecological risk factors for symptomatic and asymptomatic parasitemia in each setting;
Aim 2) Identify individual, household and ecological risk factors for gametocyte carriage during high and low transmission seasons in three distinct epidemiological settings in southern Africa;
Aim 3) Measure spatio-temporal changes in age specific antibody responses to Plasmodium falciparium antigens using sero-epidemiological surveys in the three regions of southern Africa;
Aim 4) Identify targeted, risk-based combinations of malaria control strategies that are cost-effective and acceptable to the community using mathematical modeling approaches to optimize decision algorithms based on locally available survey and surveillance data. Detailed understanding of malaria transmission dynamics in three different epidemiological settings will thus inform the development of locally-adapted, cost-effective and community-supported strategies for malaria control. These epidemiological investigations will be closely linked with studies of spatio-temporal changes in the anopheline vector and Plasmodium population structure in response to ecological changes and malaria control efforts. This integrated, evidence-based approach to malaria control will form the foundation for a regional center of excellence for malaria research in southern Africa and the foundation for regional malaria elimination.

Public Health Relevance

The burden of malaria has decreased dramatically in parts of sub-Saharan Africa within the past several years, raising the possibility of regional malaria elimination. Our research activities will provide the detailed knowledge of malaria transmission in southern Africa necessary to develop locally-adapted, targeted control strategies for the next stage of malaria control and possibly the regional elimination of malaria.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089680-04
Application #
8503406
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$353,494
Indirect Cost
$35,287
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Sutcliffe, Catherine G; Searle, Kelly; Matakala, Hellen K et al. (2016) Measles and Rubella Seroprevalence Among HIV-Infected And Uninfected Zambian Youth. Pediatr Infect Dis J :
Samuel, Michael; Oliver, Shüné V; Coetzee, Maureen et al. (2016) The larvicidal effects of black pepper (Piper nigrum L.) and piperine against insecticide resistant and susceptible strains of Anopheles malaria vector mosquitoes. Parasit Vectors 9:238
Huang, Yuzheng; Li, Wei; Lu, Wuguang et al. (2016) Cloning and in vitro characterization of a Schistosoma japonicum aquaglyceroporin that functions in osmoregulation. Sci Rep 6:35030
Kanyangarara, Mufaro; Mamini, Edmore; Mharakurwa, Sungano et al. (2016) Reduction in Malaria Incidence following Indoor Residual Spraying with Actellic 300 CS in a Setting with Pyrethroid Resistance: Mutasa District, Zimbabwe. PLoS One 11:e0151971
Dahan-Moss, Yael Leah; Koekemoer, Lizette Leonie (2016) Analysis of esterase enzyme activity in adults of the major malaria vector Anopheles funestus. Parasit Vectors 9:110
Stevenson, Jennifer C; Simubali, Limonty; Mbambara, Saidon et al. (2016) Detection of Plasmodium falciparum Infection in Anopheles squamosus (Diptera: Culicidae) in an Area Targeted for Malaria Elimination, Southern Zambia. J Med Entomol 53:1482-1487
Pinchoff, Jessie; Chaponda, Mike; Shields, Timothy M et al. (2016) Individual and Household Level Risk Factors Associated with Malaria in Nchelenge District, a Region with Perennial Transmission: A Serial Cross-Sectional Study from 2012 to 2015. PLoS One 11:e0156717
Guo, Suqin; He, Lishan; Tisch, Daniel J et al. (2016) Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings. Trop Med Health 44:15
Shields, Timothy; Pinchoff, Jessie; Lubinda, Jailos et al. (2016) Spatial and temporal changes in household structure locations using high-resolution satellite imagery for population assessment: an analysis in southern Zambia, 2006-2011. Geospat Health 11:410
Das, Smita; Muleba, Mbanga; Stevenson, Jennifer C et al. (2016) Habitat Partitioning of Malaria Vectors in Nchelenge District, Zambia. Am J Trop Med Hyg 94:1234-44

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