The proposed Center of Excellence for Malaria Research will focus on the epidemiology, vector biology and genetic diversity of malaria parasites under conditions typical of much of southern Africa. The research will be conducted in three endemic areas with different levels of malaria transmission and stages of control. The main research site will be located at the Malaria Institute at Macha (MIAM) in the Choma District of the Southern Province of Zambia. This is a semi-arid region that has a history of intense seasonal malaria transmission. While chemotherapy to reduce deaths from malaria has been in effect for over 20 years, no vector control interventions were implemented until 2007. The second field site will be at the Tropical Disease Research Centre (TDRC) in the Nchelenge District in the Luapula Province in northern Zambia, in the environs of Lake Mweru. This is a high transmission area with hyper- to holo-endemic malaria. The third field site will be at the Biomedical Research Training Institute (BRTI) in Mutasa District in Manicaland Province, Zimbabwe. This region was under an effective malaria control program for about 50 years but the program was terminated in the late 1990's. Consequently, there has been a resurgence of malaria. The ecological, geographical and demographic differences between these research areas provide a range of epidemiological conditions to investigate malaria transmission and control in southern Africa, specifically spatio-temporal patterns of transmission, vector biology and parasite diversity. Studies of malaria epidemiology will focus on hospital, clinic and community-based prospective studies to track spatial and temporal changes in transmission. Population genetic studies of the vector and parasite will allow characterization of the genetic heterogeneity associated with natural and imposed bottle necks and the changing frequency of insecticide resistance and antimalarial resistance mutations. The project Cores, consisting of Environmental Surveillance, Genomics and Data Management/Biostatistics provide links between the three research areas. An integrated relational data base will link information across space and time. The Training/Career Development Program will be coordinated at the University of Zambia and the Johns Hopkins School of Public Health and will take advantage of local capacity to strengthen their training programs to ensure the Center of Excellence for Malaria Research is sustained after the completion of this program.
Despite progress in malaria control, the southern Africa region continues to have a diversity of malaria transmission and control efforts. The proposed research activities will provide the detailed knowledge of malaria transmission, including epidemiology, vector biology and parasite population structure, to develop locally-adapted, targeted control strategies for the regional elimination of malaria.
|Searle, Kelly M; Lubinda, Jailos; Hamapumbu, Harry et al. (2017) Characterizing and quantifying human movement patterns using GPS data loggers in an area approaching malaria elimination in rural southern Zambia. R Soc Open Sci 4:170046|
|Das, Smita; Muleba, Mbanga; Stevenson, Jennifer C et al. (2017) Beyond the entomological inoculation rate: characterizing multiple blood feeding behavior and Plasmodium falciparum multiplicity of infection in Anopheles mosquitoes in northern Zambia. Parasit Vectors 10:45|
|Sutcliffe, Catherine G; Searle, Kelly; Matakala, Hellen K et al. (2017) Measles and Rubella Seroprevalence Among HIV-infected and Uninfected Zambian Youth. Pediatr Infect Dis J 36:301-306|
|Ippolito, Matthew M; Searle, Kelly M; Hamapumbu, Harry et al. (2017) House Structure Is Associated with Plasmodium falciparum Infection in a Low-Transmission Setting in Southern Zambia. Am J Trop Med Hyg 97:1561-1567|
|Venter, Nelius; Oliver, Sh?né V; Muleba, Mbanga et al. (2017) Benchmarking insecticide resistance intensity bioassays for Anopheles malaria vector species against resistance phenotypes of known epidemiological significance. Parasit Vectors 10:198|
|Searle, Kelly M; Katowa, Ben; Kobayashi, Tamaki et al. (2017) Distinct parasite populations infect individuals identified through passive and active case detection in a region of declining malaria transmission in southern Zambia. Malar J 16:154|
|Kanyangarara, Mufaro; Mamini, Edmore; Mharakurwa, Sungano et al. (2016) Individual- and Household-Level Risk Factors Associated with Malaria in Mutasa District, Zimbabwe: A Serial Cross-Sectional Study. Am J Trop Med Hyg 95:133-40|
|Stevenson, Jennifer C; Pinchoff, Jessie; Muleba, Mbanga et al. (2016) Spatio-temporal heterogeneity of malaria vectors in northern Zambia: implications for vector control. Parasit Vectors 9:510|
|Guo, Suqin; He, Lishan; Tisch, Daniel J et al. (2016) Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings. Trop Med Health 44:15|
|Stevenson, Jennifer C; Norris, Douglas E (2016) Implicating Cryptic and Novel Anophelines as Malaria Vectors in Africa. Insects 8:|
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