The Administrative Core based at the Johns Hopkins Malaria Research Institute (JHMRI) at the Bloomberg School of Public Health (JHSPH) will be responsible for the overall administration, coordination and management of the Center of Excellence for Malaria Research in southern Africa. Dr. Peter Agre, a Nobel Prize winning physician-scientist and Director ofthe JHMRI, will be the Principal Investigator and the Core Leader ofthe Administrative Core. Dr. Agre, in conjunction with the Research Area Project Leaders and the Core Leaders (Data Management/Biostatistics, Environmental Surveillance, and Genomics) will have overall responsibility for managing, coordinating and supervising Center activities, and ensuring that project milestones are met within the proposed timelines. Dr. William Moss, Research Area A Project Leader, will assist Dr. Agre in these activities as Project Co-investigator. In addition to Dr. Agre, the Administrative Core at JHMRI will consist of a Research Administrator, Genevieve Nixon, and a Senior Financial Analyst, Meredith Piplani. Dr. Clive Shiff will assist with the Training and Career Development Program as part ofthe Administrative Core. Utilizing existing recruitment structures and candidate selection process, the University of Zambia (UNZA) will recruit at least two post-doctoral candidates, junior faculty or established investigators to participate in a JHSPH- and UNZA-led training program designed to prepare scientists for careers in malaria research. Project activities will also be administered and managed at the Centers of Excellence established in southern Zambia, specifically the Malaria Institute at Macha (MIAM), Tropical Diseases Research Centre (TDRC) and University of Zambia (UNZA) in Zambia and the Biomedical Research and Training Institute (BRTI) in Zimbabwe. Each of these sites will have an overall project supervisor, administrative assistant and financial analyst. Communication between JHMRI and the sites in southern Africa will be facilitated through a project website that will allow for the rapid transmission of information and documents between all project scientists. Over the course ofthe project, and as a consequence of training, career development and capacity building, project administration and coordination will increasingly be based at the sites in Zambia and Zimbabwe. The goal is to build the capacity of endemic country scientists, to conduct high quality malaria research, to establish a sustainable Center of Excellence for Malaria Research, and to further malaria control. The Administrative Core is prepared to host all other Centers for the first Annual Workshop in Victoria Falls, Zambia.

Public Health Relevance

Recent progress in malaria control suggests that malaria elimination may be possible in southern Africa, but further progress requires detailed understanding ofthe changing epidemiology, vector biology and parasite biology within different epidemiological contexts within the region. The Administrative Core will ensure the coordination and integration across these research and geographical areas to achieve the malaria control goals.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089680-05
Application #
8689889
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Comfort, Alison B; van Dijk, Janneke H; Mharakurwa, Sungano et al. (2014) Association between malaria control and paediatric blood transfusions in rural Zambia: an interrupted time-series analysis. Malar J 13:383
Mharakurwa, Sungano; Daniels, Rachel; Scott, Alan et al. (2014) Pre-amplification methods for tracking low-grade Plasmodium falciparum populations during scaled-up interventions in Southern Zambia. Malar J 13:89
Ricotta, Emily E; Frese, Steven A; Choobwe, Cornelius et al. (2014) Evaluating local vegetation cover as a risk factor for malaria transmission: a new analytical approach using ImageJ. Malar J 13:94
Liu, Kun; Dong, Yuemei; Huang, Yuzheng et al. (2013) Impact of trehalose transporter knockdown on Anopheles gambiae stress adaptation and susceptibility to Plasmodium falciparum infection. Proc Natl Acad Sci U S A 110:17504-9
Norris, Laura C; Norris, Douglas E (2013) Heterogeneity and changes in inequality of malaria risk after introduction of insecticide-treated bed nets in Macha, Zambia. Am J Trop Med Hyg 88:710-7
Tsujimoto, Hitoshi; Liu, Kun; Linser, Paul J et al. (2013) Organ-specific splice variants of aquaporin water channel AgAQP1 in the malaria vector Anopheles gambiae. PLoS One 8:e75888
Promeneur, Dominique; Lunde, Lisa Kristina; Amiry-Moghaddam, Mahmood et al. (2013) Protective role of brain water channel AQP4 in murine cerebral malaria. Proc Natl Acad Sci U S A 110:1035-40
Moss, William J; Norris, Douglas E; Mharakurwa, Sungano et al. (2012) Challenges and prospects for malaria elimination in the Southern Africa region. Acta Trop 121:207-11
Mharakurwa, Sungano; Thuma, Philip E; Norris, Douglas E et al. (2012) Malaria epidemiology and control in Southern Africa. Acta Trop 121:202-6
Mharakurwa, Sungano; Kumwenda, Taida; Mkulama, Mtawa A P et al. (2011) Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes. Proc Natl Acad Sci U S A 108:18796-801