Core C - Shared Laboratory Resources Core C will centralize and maintain quality control for parasitological and immunological procedures required by the five Projects that comprise the Center, so that the efficient use of equipment and reagent resources is maximized. This includes coordination, performance and monitoring of all work related to parasitological, immunological, nucleic acid and recombinant protein-related procedures, immunological analyses, and bioinformatics analyses among the Projects and the Data Management Core. This Core will also be critical for research capacity building with regard to data sets such as those arising from DNA, gene expression, and protein microarray experiments done in the US (at UCSD and UC Irvine, respectively) because of lack of availability in Peru or Brazil. Analysis of these data sets will be carried out by Project leaders in collaboration with the Bioinformatics unit of Core C, under the direction of Professor Mirko Zimic. This core will centralize collection and handling procedures for biological specimens, register and collation of assay results, transfer and diffusion of acquired technology and will also provide the environment for laboratory-based training for University students, postdoctoral trainees, and visiting investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089681-04
Application #
8512555
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$240,046
Indirect Cost
$18,596
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Rodrigues, Priscila T; Valdivia, Hugo O; de Oliveira, Thais C et al. (2018) Human migration and the spread of malaria parasites to the New World. Sci Rep 8:1993
Moreno, Marta; Tong-Rios, Carlos; Orjuela-Sanchez, Pamela et al. (2018) Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon. ACS Infect Dis 4:541-548
Prussing, Catharine; Moreno, Marta; Saavedra, Marlon P et al. (2018) Decreasing proportion of Anopheles darlingi biting outdoors between long-lasting insecticidal net distributions in peri-Iquitos, Amazonian Peru. Malar J 17:86
Martin, Thomas C S; Vinetz, Joseph M (2018) Asymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination. Malar J 17:89
Junqueira, Caroline; Barbosa, Camila R R; Costa, Pedro A C et al. (2018) Cytotoxic CD8+ T cells recognize and kill Plasmodium vivax-infected reticulocytes. Nat Med 24:1330-1336
Cowell, Annie N; Valdivia, Hugo O; Bishop, Danett K et al. (2018) Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing. Genome Med 10:52
Schrum, Jacob E; Crabtree, Juliet N; Dobbs, Katherine R et al. (2018) Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity. J Immunol 200:1243-1248
White, Sara E; Harvey, Steven A; Meza, Graciela et al. (2018) Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study. Malar J 17:179
Hirako, Isabella Cristina; Assis, Patrícia Aparecida; Hojo-Souza, Natália Satchiko et al. (2018) Daily Rhythms of TNF? Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle. Cell Host Microbe 23:796-808.e6
Prussing, Catharine; Bickersmith, Sara A; Moreno, Marta et al. (2018) Nyssorhynchus dunhami: bionomics and natural infection by Plasmodium falciparum and P. vivax in the Peruvian Amazon. Mem Inst Oswaldo Cruz 113:e180380

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