The overall goal ofthe Epidemiology Project is to advance understanding of how reductions in malaria transmission mediated by sustained, intensified public health interventions that include universal deployment of long lasfing insecficide treated bed nets (LLINs) and artemisin combination treatment (ACT) alter the complex relationship between Plasmodium spp. parasites, malaria vectors and the human host in ways that can be translated to monitoring, evaluating and guiding regional and national malaria control programs. Major features of the project include i) three study sites that signify the breadth of P. falciparum and P. vivax endemicity and transmission potential in the SE Asia/Pacific region, ranging from holoendemic (north coast mainland Papua New Guinea [PNG]), meso/hyperendemic (East New Britain PNG), and hypoendemic (Western Province, Solomon Islands), ii) the execution of similar study designs in all three sites (longitudinal age-stratified childhood cohort studies and community surveillance for infection and morbidity), iii) the opportunity to compare directly the impact of interventions on control and elimination of P. falciparum versus P. vivax and, iv) close ties with national malaria control programs in the region.
The specific aims are to; 1) Determine the effect of sustained control on patterns of Plasmodium spp infections and their contribution to malarial morbidity in children 1-5 years of age living in 3 areas with differing malaria endemicity 2) Assess effect of sustained control on force, complexity and dynamics of Plasmodium infections in children 6-12 years of age 3) Determine changes in the age-specific prevalence of infection and malaria-attributable illness 4) Study the gametocyte dynamics in P. falciparum and P. vivax infections 5) Monitor the changes in genetic diversity of Plasmodium spp. infections in the context of intensifying control activities Project 1 is central to the synergy of the ICEMR since Research Projects 2 (transmission) and 3 (Pathogenesis/immunity) will be done in the same endemic sites, with data shared and laboratory tests conducted by Core B (Database) and Core C (Molecular Diagnosfics).

Public Health Relevance

Nafional malaria control programs in SE Asia and elsewhere are now gearing up to deploy LLINs and implement ACT in order to improve malaria control, i.e. reduce the burden of morbidity and ultimately, eliminate malaria locally then regionally. Understanding how malaria intervenfions differentially alter infection and morbidity in pre-intervention settings that range from high to low transmission potential are essential to evidence-based management of such public health efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089686-04
Application #
8494537
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
2013-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$516,146
Indirect Cost
$84,673
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Kurtovic, Liriye; Behet, Marije C; Feng, Gaoqian et al. (2018) Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children. BMC Med 16:61
Koepfli, Cristian; Waltmann, Andreea; Ome-Kaius, Maria et al. (2018) Multiplicity of Infection Is a Poor Predictor of Village-Level Plasmodium vivax and P. falciparum Population Prevalence in the Southwest Pacific. Open Forum Infect Dis 5:ofy240
Liu, Eugene W; Skinner, Jeff; Tran, Tuan M et al. (2018) Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens. Am J Trop Med Hyg 98:57-66
Nakajima, Rie; Supnet, Medalyn; Jasinskas, Algis et al. (2018) Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies. mSphere 3:
Waltmann, Andreea; Koepfli, Cristian; Tessier, Natacha et al. (2018) Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. PLoS Negl Trop Dis 12:e0006146
Koimbu, Gussy; Czeher, Cyrille; Katusele, Michelle et al. (2018) Status of Insecticide Resistance in Papua New Guinea: An Update from Nation-Wide Monitoring of Anopheles Mosquitoes. Am J Trop Med Hyg 98:162-165
White, Michael T; Karl, Stephan; Koepfli, Cristian et al. (2018) Plasmodium vivax and Plasmodium falciparum infection dynamics: re-infections, recrudescences and relapses. Malar J 17:170
Hofmann, Natalie E; Karl, Stephan; Wampfler, Rahel et al. (2017) The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea. Elife 6:
França, Camila Tenorio; White, Michael T; He, Wen-Qiang et al. (2017) Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development. Elife 6:
França, Camila T; Li Wai Suen, Connie S N; Carmagnac, Amandine et al. (2017) IgG antibodies to synthetic GPI are biomarkers of immune-status to both Plasmodium falciparum and Plasmodium vivax malaria in young children. Malar J 16:386

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