The overall goal ofthe Epidemiology Project is to advance understanding of how reductions in malaria transmission mediated by sustained, intensified public health interventions that include universal deployment of long lasfing insecficide treated bed nets (LLINs) and artemisin combination treatment (ACT) alter the complex relationship between Plasmodium spp. parasites, malaria vectors and the human host in ways that can be translated to monitoring, evaluating and guiding regional and national malaria control programs. Major features of the project include i) three study sites that signify the breadth of P. falciparum and P. vivax endemicity and transmission potential in the SE Asia/Pacific region, ranging from holoendemic (north coast mainland Papua New Guinea [PNG]), meso/hyperendemic (East New Britain PNG), and hypoendemic (Western Province, Solomon Islands), ii) the execution of similar study designs in all three sites (longitudinal age-stratified childhood cohort studies and community surveillance for infection and morbidity), iii) the opportunity to compare directly the impact of interventions on control and elimination of P. falciparum versus P. vivax and, iv) close ties with national malaria control programs in the region.
The specific aims are to; 1) Determine the effect of sustained control on patterns of Plasmodium spp infections and their contribution to malarial morbidity in children 1-5 years of age living in 3 areas with differing malaria endemicity 2) Assess effect of sustained control on force, complexity and dynamics of Plasmodium infections in children 6-12 years of age 3) Determine changes in the age-specific prevalence of infection and malaria-attributable illness 4) Study the gametocyte dynamics in P. falciparum and P. vivax infections 5) Monitor the changes in genetic diversity of Plasmodium spp. infections in the context of intensifying control activities Project 1 is central to the synergy of the ICEMR since Research Projects 2 (transmission) and 3 (Pathogenesis/immunity) will be done in the same endemic sites, with data shared and laboratory tests conducted by Core B (Database) and Core C (Molecular Diagnosfics).

Public Health Relevance

Nafional malaria control programs in SE Asia and elsewhere are now gearing up to deploy LLINs and implement ACT in order to improve malaria control, i.e. reduce the burden of morbidity and ultimately, eliminate malaria locally then regionally. Understanding how malaria intervenfions differentially alter infection and morbidity in pre-intervention settings that range from high to low transmission potential are essential to evidence-based management of such public health efforts.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089686-04
Application #
8494537
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
2013-07-01
Project End
2017-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$516,146
Indirect Cost
$84,673
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
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Echeverry, Diego F; Deason, Nicholas A; Davidson, Jenna et al. (2016) Human malaria diagnosis using a single-step direct-PCR based on the Plasmodium cytochrome oxidase III gene. Malar J 15:128
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Russell, Tanya L; Beebe, Nigel W; Bugoro, Hugo et al. (2016) Frequent blood feeding enables insecticide-treated nets to reduce transmission by mosquitoes that bite predominately outdoors. Malar J 15:156
Guo, Suqin; He, Lishan; Tisch, Daniel J et al. (2016) Pilot testing of dipsticks as point-of-care assays for rapid diagnosis of poor-quality artemisinin drugs in endemic settings. Trop Med Health 44:15
Russell, Tanya L; Burkot, Thomas R; Bugoro, Hugo et al. (2016) Larval habitats of the Anopheles farauti and Anopheles lungae complexes in the Solomon Islands. Malar J 15:164
Jain, Aarti; Taghavian, Omid; Vallejo, Derek et al. (2016) Evaluation of quantum dot immunofluorescence and a digital CMOS imaging system as an alternative to conventional organic fluorescence dyes and laser scanning for quantifying protein microarrays. Proteomics 16:1271-9

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