The Administrative Core of this SE Asia/Pacific ICEMR involving Papua New Guinea (PNG) and Solomon Islands (SI) (later, Vanuatu) are to: 1) Implement and coordinate ICEMR activities to ensure compliance with the guidelines and regulations of NIH and endemic country institutions 2) Maintain financial oversight and account for disbursement of funds to the research projects and cores 3) Coordinate scientific and training activities among the projects and cores 4) Assure and stimulate interaction with other groups concerned with malaria control and elimination. Including those supported by the NIH ICEMR program and other funding agencies 5) Track progress on the research, capacity building and educational goals ofthe ICEMR in order to make evidence-based decisions regarding allocation of funding and other resources available to the ICEMR The Administrative Core will be located at CWRU where the PD, J Kazura, and key administrative liaison staff have primary appointments. The on-site Administrative Core mirror site Is in PNG where Co-PD administrative leaders, P Siba and I Mueller, are based. Activities of Solomon Islands Co-PD, Albino Bobogare, will be facilitated by managerial support from the Pacific Malaria Initiative through the University of Queensland (UQ). The current strong relationships among the Institutions within the Administrative Core (CWRU-PNG Institute of Medical Research;UQ-Solomon Islands Vector Borne Disease Control Programme) will ensure efficiency and transparency of decision-making that will be made in conjunction with the ICEMR Program Executive Committee, an external Scientific Advisory Group and NIH. Highest priority will be given to executing ICEMR research activities in malaria endemic countries and building research infrastructure and training capacity in this setting. The Administrative Core will interact regulariy with national programs responsible for malaria control and elimination in order to transfer research findings to policy where appropriate.

Public Health Relevance

The research, training and infrastructure building goals ofthe ICEMR have complex sets of activities that need to be conducted in accordance with fiduciary and regulatory requirements of NIH and participating institutions and countries. The governance ofthe Administrative Core is designed to meet these requirements, and to engage national malaria control program leadershship so that ICEMR outcomes in research and training can be used to advance malaria control and elimination at a population level.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-AWA-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Case Western Reserve University
United States
Zip Code
Kurtovic, Liriye; Behet, Marije C; Feng, Gaoqian et al. (2018) Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children. BMC Med 16:61
Koepfli, Cristian; Waltmann, Andreea; Ome-Kaius, Maria et al. (2018) Multiplicity of Infection Is a Poor Predictor of Village-Level Plasmodium vivax and P. falciparum Population Prevalence in the Southwest Pacific. Open Forum Infect Dis 5:ofy240
Liu, Eugene W; Skinner, Jeff; Tran, Tuan M et al. (2018) Protein-Specific Features Associated with Variability in Human Antibody Responses to Plasmodium falciparum Malaria Antigens. Am J Trop Med Hyg 98:57-66
Nakajima, Rie; Supnet, Medalyn; Jasinskas, Algis et al. (2018) Protein Microarray Analysis of the Specificity and Cross-Reactivity of Influenza Virus Hemagglutinin-Specific Antibodies. mSphere 3:
Waltmann, Andreea; Koepfli, Cristian; Tessier, Natacha et al. (2018) Increasingly inbred and fragmented populations of Plasmodium vivax associated with the eastward decline in malaria transmission across the Southwest Pacific. PLoS Negl Trop Dis 12:e0006146
Koimbu, Gussy; Czeher, Cyrille; Katusele, Michelle et al. (2018) Status of Insecticide Resistance in Papua New Guinea: An Update from Nation-Wide Monitoring of Anopheles Mosquitoes. Am J Trop Med Hyg 98:162-165
White, Michael T; Karl, Stephan; Koepfli, Cristian et al. (2018) Plasmodium vivax and Plasmodium falciparum infection dynamics: re-infections, recrudescences and relapses. Malar J 17:170
Hofmann, Natalie E; Karl, Stephan; Wampfler, Rahel et al. (2017) The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea. Elife 6:
França, Camila Tenorio; White, Michael T; He, Wen-Qiang et al. (2017) Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development. Elife 6:
França, Camila T; Li Wai Suen, Connie S N; Carmagnac, Amandine et al. (2017) IgG antibodies to synthetic GPI are biomarkers of immune-status to both Plasmodium falciparum and Plasmodium vivax malaria in young children. Malar J 16:386

Showing the most recent 10 out of 84 publications