Currently, they are a variety of malaria control strategies being implemented in sub-Sahara Africa as result of international community effort to eliminate malaria. However, these interventions are not well Integrated and often experience low rate of correct usage. The overall goal of this project is to enable operational program managers to achieve optimal implementation of malaria control techniques, by assessing the effectiveness of various combinations of specific malaria control techniques under different epidemiological conditions, and by assessing the effects of malaria control on biological outcomes (e.g. drug resistant parasite population, clinical presentation of malaria cases, innate immune response pattern, vector resistance to insecticides or different patterns of vector behavior). The first specific aim address the need for baseline data on the burden of P. falciparum infection and malaria illness in relation to transmission risks at four different ecological settings in The Gambia (low seasonal transmission), Mali (irrigated areas and Sudan Savana) and Senegal (urban setting).
The specific aim 2 Assess the impact of the current ongoing malaria control efforts, using different combination of approaches. The integrated malaria control strategies will be optimized, implemented and monitored to provide evidence of the impact of ongoing malaria control strategy. Finally as successful malaria control strategies evolve toward elimination, the aim 3 Investigate the relationship between pregnancy and childhood infection and illness in the context of an integrated malaria control program. The project not only will contribute to provide plausible evidence of the impact of integrated malaria control strategies being assessed, but also allow to detect any emerging insecticide or drug resistance, and adjust strategy in timely manner.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089696-05
Application #
8691372
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Mbaye, Aminata; Gaye, Amy; Dieye, Baba et al. (2017) Ex vivo susceptibility and genotyping of Plasmodium falciparum isolates from Pikine, Senegal. Malar J 16:250
Koita, Ousmane A; Sangaré, Lansana; Miller, Haiyan D et al. (2017) AQ-13, an investigational antimalarial, versus artemether plus lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria: a randomised, phase 2, non-inferiority clinical trial. Lancet Infect Dis 17:1266-1275
Ndiaye, Yaye Dié; Diédhiou, Cyrille K; Bei, Amy K et al. (2017) High resolution melting: a useful field-deployable method to measure dhfr and dhps drug resistance in both highly and lowly endemic Plasmodium populations. Malar J 16:153
Talundzic, Eldin; Ndiaye, Yaye D; Deme, Awa B et al. (2017) Molecular Epidemiology of Plasmodium falciparum kelch13 Mutations in Senegal Determined by Using Targeted Amplicon Deep Sequencing. Antimicrob Agents Chemother 61:
Koita, Ousmane A; Murphy, Robert L; Fongoro, Saharé et al. (2016) Clinical Research and the Training of Host Country Investigators: Essential Health Priorities for Disease-Endemic Regions. Am J Trop Med Hyg 94:253-7
Dieye, Baba; Affara, Muna; Sangare, Lassana et al. (2016) West Africa International Centers of Excellence for Malaria Research: Drug Resistance Patterns to Artemether-Lumefantrine in Senegal, Mali, and The Gambia. Am J Trop Med Hyg 95:1054-1060
Mbaye, Aminata; Dieye, Baba; Ndiaye, Yaye D et al. (2016) Selection of N86F184D1246 haplotype of Pfmrd1 gene by artemether-lumefantrine drug pressure on Plasmodium falciparum populations in Senegal. Malar J 15:433
Carlton, Jane M; Volkman, Sarah K; Uplekar, Swapna et al. (2015) Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research. Am J Trop Med Hyg 93:87-98
Cui, Liwang; Mharakurwa, Sungano; Ndiaye, Daouda et al. (2015) Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg 93:57-68
Moss, William J; Dorsey, Grant; Mueller, Ivo et al. (2015) Malaria Epidemiology and Control Within the International Centers of Excellence for Malaria Research. Am J Trop Med Hyg 93:5-15

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