The main objective of this project Is to determine the clinical outcomes and their association with parasite and host features of malaria-infected individuals living In non-Amazon regions of Latin America (LA) with different intensities of malaria transmission. It is hypothesized that clinical manifestations of malaria in infected individuals living in high malaria transmission areas are different from those observed in low transmission areas in which both parasites P. vivax and P. falciparum co-exist. These studies will be conducted through the following specific alms: 1) establishment of the clinical profile of malaria In different epidemiological settings and their association with parasite and host immunological status:;2) assess the prevalence of malaria mixed infections and its influence in the clinical outcomes of the disease;3) determine the prevalence of hematological manifestations related to malaria infection and their association with concomitant immune status nutritional factors, and helminth co-infections, and 4) determine the prevalence of placental malaria and Its impact on neonatal health and child development. This is a multisite center study in Latin America in which cross-sectional, cohort studies and longitudinal and cohort studies will be performed In 3,600 individuals for alms 1-3 and 200 newborns for aim 4. Parasitological, hematological, and immunological evaluations will be performed and concomitant non-malaria infections will be evaluated. The impact of malaria on child growth and development and level of impairment will be assessed using locally standardized questionnaires based on International guidelines (BMI and ICF). The overall studies proposed in this project will not only provide a better understanding ofthe immunopathogenesis of malaria in LA but will also generate useful Information for malaria case management, control strategies including antimalaria therapy, future use of malaria vaccine and points of intervention to improve developmental outcomes of children living in malaria endemic regions of LA.

Public Health Relevance

Coordinated multi-site studies on malaria immunopathogenesis will be conducted in three countries of Latin America. This will be the first large-scale comprehensive study on malaria Immunopatogenesis of malaria in low-to-moderate malaria endemic regions of Latin America.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089702-05
Application #
8711220
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Caucaseco Scientific Research Center
Department
Type
DUNS #
City
Cali
State
Country
Colombia
Zip Code
Ding, Xavier C; Ade, Maria Paz; Baird, J Kevin et al. (2017) Defining the next generation of Plasmodium vivax diagnostic tests for control and elimination: Target product profiles. PLoS Negl Trop Dis 11:e0005516
Céspedes, Nora; Li Wai Suen, Connie S N; Koepfli, Cristian et al. (2017) Natural immune response to Plasmodium vivax alpha-helical coiled coil protein motifs and its association with the risk of P. vivax malaria. PLoS One 12:e0179863
Sáenz, Fabián E; Arévalo-Cortés, Andrea; Valenzuela, Gabriela et al. (2017) Malaria epidemiology in low-endemicity areas of the northern coast of Ecuador: high prevalence of asymptomatic infections. Malar J 16:300
Chaparro, Pablo E; Molina, Karen; Alzate, Alberto et al. (2017) Urban malaria transmission in a non-endemic area in the Andean region of Colombia. Mem Inst Oswaldo Cruz 112:797-804
Recht, Judith; Siqueira, André M; Monteiro, Wuelton M et al. (2017) Malaria in Brazil, Colombia, Peru and Venezuela: current challenges in malaria control and elimination. Malar J 16:273
Kim, Adam; Popovici, Jean; Vantaux, Amélie et al. (2017) Characterization of P. vivax blood stage transcriptomes from field isolates reveals similarities among infections and complex gene isoforms. Sci Rep 7:7761
Molina Gómez, Karen; Caicedo, M Alejandra; Gaitán, Alexandra et al. (2017) Characterizing the malaria rural-to-urban transmission interface: The importance of reactive case detection. PLoS Negl Trop Dis 11:e0005780
Vallejo, Andrés F; Rubiano, Kelly; Amado, Andres et al. (2016) Optimization of a Membrane Feeding Assay for Plasmodium vivax Infection in Anopheles albimanus. PLoS Negl Trop Dis 10:e0004807
Ahumada, Martha L; Orjuela, Lorena I; Pareja, Paula X et al. (2016) Spatial distributions of Anopheles species in relation to malaria incidence at 70 localities in the highly endemic Northwest and South Pacific coast regions of Colombia. Malar J 15:407
Chaurio, Ricardo A; Pacheco, M Andreína; Cornejo, Omar E et al. (2016) Evolution of the Transmission-Blocking Vaccine Candidates Pvs28 and Pvs25 in Plasmodium vivax: Geographic Differentiation and Evidence of Positive Selection. PLoS Negl Trop Dis 10:e0004786

Showing the most recent 10 out of 81 publications