The proposed U19 program involves investigators at five different locations (Baylor Institute for Immunology Research, Dallas, TX;Nationwide Children's Hospital, Columbus, OH;Dynavax Technologies, Berkeley, CA; Mount Sinai School of Medicine, New York, NY;and University of California Santa Cruz, Santa Cruz, CA). Five Projects and seven Cores are planned. An annual symposium is proposed. Therefore, there is considerable need to coordinate and support the various activities. The Administrative Core A will be responsible for this coordination and support: To coordinate all Program components and ensure communication between Investigators. ? To provide Investigators with help in management of budgets and personnel issues. ? To organize meetings, meeting reports and annual NIH reports. ? To oversee issues related to intellectual property and regulatory issues related to research using human subjects. To provide access to a data management infrastructure.

Public Health Relevance

The proposed U19 program will involve investigators from five different institutions (in Dallas, TX;Berkeley, CA;Santa Cruz, CA;Columbus, OH and New York, NY). The Administrative Core will provide coordination and support for all members ofthe program as well as organize an annual symposium that is funded by this grant.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089987-03
Application #
8376050
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$76,337
Indirect Cost
$16,900
Name
Baylor Research Institute
Department
Type
DUNS #
145745022
City
Dallas
State
TX
Country
United States
Zip Code
75204
Cepika, Alma-Martina; Banchereau, Romain; Segura, Elodie et al. (2017) A multidimensional blood stimulation assay reveals immune alterations underlying systemic juvenile idiopathic arthritis. J Exp Med 214:3449-3466
Athale, Shruti; Banchereau, Romain; Thompson-Snipes, LuAnn et al. (2017) Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets. Sci Transl Med 9:
Schotsaert, Michael; García-Sastre, Adolfo (2017) Inactivated influenza virus vaccines: the future of TIV and QIV. Curr Opin Virol 23:102-106
Silvin, Aymeric; Yu, Chun I; Lahaye, Xavier et al. (2017) Constitutive resistance to viral infection in human CD141+ dendritic cells. Sci Immunol 2:
Sandoval, Carmen; Barrera, Aldo; Ferrés, Marcela et al. (2016) Infection in Health Personnel with High and Low Levels of Exposure in a Hospital Setting during the H1N1 2009 Influenza A Pandemic. PLoS One 11:e0147271
Heinonen, Santtu; Jartti, Tuomas; Garcia, Carla et al. (2016) Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis. Am J Respir Crit Care Med 193:772-82
Blohmke, Christoph J; Darton, Thomas C; Jones, Claire et al. (2016) Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. J Exp Med 213:1061-77
Schmitt, Nathalie; Liu, Yang; Bentebibel, Salah-Eddine et al. (2016) Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans. Cell Rep 16:1082-1095
Bentebibel, Salah-Eddine; Khurana, Surender; Schmitt, Nathalie et al. (2016) ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination. Sci Rep 6:26494
Suarez, Nicolas M; Bunsow, Eleonora; Falsey, Ann R et al. (2015) Superiority of transcriptional profiling over procalcitonin for distinguishing bacterial from viral lower respiratory tract infections in hospitalized adults. J Infect Dis 212:213-22

Showing the most recent 10 out of 57 publications