The objectives of the Pilot Projects are two-fold. This proposal brings together a group of experts that synergize to provide the best possible program on the topic of Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans. Given the breadth of the topic, we should expect to identify gaps in the repertoire of collective expertise. The first objective of these Pilot Projects will be to fill any knowledge gaps that are identified and expand the discoveries made in the program. The second objective will be to develop areas of research that can expand to independently funded projects in the future. The five years of the program could permit us to support several Pilot Projects. These projects will be financed for up to two years. It is proposed that each Pilot Project will be overseen/chaperoned from inception to completion by two of the program's investigators. The proposed Pilot Projects are: Pilot Project 1: DNA Template Recycling for Deep Sequencing and Identification of Immunoglobulin VDJ gene Usage in Response to Influenza Vaccine (Co-PIs: Nader Pourmand, David Haussler, and Martha Zuniga;University of California Santa Cruz) Pilot Project 2: Deep Sequence Analysis of B-Cell Responses to Vaccines in SLE Patients with High IFN alpha and Low IFN alpha Signatures and in JDM Patients (Co-PIs: Martha Zuniga, David Haussler, and Nader Pourmand;University of California Santa Cruz) Pilot Project 3: To Investigate the Effect of IL-12/IL-23 Blockade on Response to Vaccination in Patients with Chronic Plaque Psoriasis (PI: Alan Menter;Texas Dermatology Associates, PA &Baylor Institute for Immunology Research)

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI089987-04
Application #
8501332
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$8,315
Indirect Cost
$1,837
Name
Baylor Research Institute
Department
Type
DUNS #
145745022
City
Dallas
State
TX
Country
United States
Zip Code
75204
Heinonen, Santtu; Jartti, Tuomas; Garcia, Carla et al. (2016) Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis. Am J Respir Crit Care Med 193:772-82
Schmitt, Nathalie; Liu, Yang; Bentebibel, Salah-Eddine et al. (2016) Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans. Cell Rep 16:1082-95
Bentebibel, Salah-Eddine; Khurana, Surender; Schmitt, Nathalie et al. (2016) ICOS(+)PD-1(+)CXCR3(+) T follicular helper cells contribute to the generation of high-avidity antibodies following influenza vaccination. Sci Rep 6:26494
de Steenhuijsen Piters, Wouter A A; Heinonen, Santtu; Hasrat, Raiza et al. (2016) Nasopharyngeal Microbiota, Host Transcriptome, and Disease Severity in Children with Respiratory Syncytial Virus Infection. Am J Respir Crit Care Med 194:1104-1115
Blohmke, Christoph J; Darton, Thomas C; Jones, Claire et al. (2016) Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever. J Exp Med 213:1061-77
Sandoval, Carmen; Barrera, Aldo; Ferrés, Marcela et al. (2016) Infection in Health Personnel with High and Low Levels of Exposure in a Hospital Setting during the H1N1 2009 Influenza A Pandemic. PLoS One 11:e0147271
Ueno, Hideki; Banchereau, Jacques; Vinuesa, Carola G (2015) Pathophysiology of T follicular helper cells in humans and mice. Nat Immunol 16:142-52
Schmitt, Nathalie; Ueno, Hideki (2015) Regulation of human helper T cell subset differentiation by cytokines. Curr Opin Immunol 34:130-6
Turner, Jacob A; Bolen, Christopher R; Blankenship, Derek M (2015) Quantitative gene set analysis generalized for repeated measures, confounder adjustment, and continuous covariates. BMC Bioinformatics 16:272
Zitvogel, Laurence; Galluzzi, Lorenzo; Viaud, Sophie et al. (2015) Cancer and the gut microbiota: an unexpected link. Sci Transl Med 7:271ps1

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