The objectives of the Pilot Projects are two-fold. This proposal brings together a group of experts that synergize to provide the best possible program on the topic of Systems Analysis of Vaccine Responses in Healthy and Hyporesponsive Humans. Given the breadth of the topic, we should expect to identify gaps in the repertoire of collective expertise. The first objective of these Pilot Projects will be to fill any knowledge gaps that are identified and expand the discoveries made in the program. The second objective will be to develop areas of research that can expand to independently funded projects in the future. The five years of the program could permit us to support several Pilot Projects. These projects will be financed for up to two years. It is proposed that each Pilot Project will be overseen/chaperoned from inception to completion by two of the program's investigators. The proposed Pilot Projects are: Pilot Project 1: DNA Template Recycling for Deep Sequencing and Identification of Immunoglobulin VDJ gene Usage in Response to Influenza Vaccine (Co-PIs: Nader Pourmand, David Haussler, and Martha Zuniga;University of California Santa Cruz) Pilot Project 2: Deep Sequence Analysis of B-Cell Responses to Vaccines in SLE Patients with High IFN alpha and Low IFN alpha Signatures and in JDM Patients (Co-PIs: Martha Zuniga, David Haussler, and Nader Pourmand;University of California Santa Cruz) Pilot Project 3: To Investigate the Effect of IL-12/IL-23 Blockade on Response to Vaccination in Patients with Chronic Plaque Psoriasis (PI: Alan Menter;Texas Dermatology Associates, PA &Baylor Institute for Immunology Research)

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-QV-I)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Baylor Research Institute
United States
Zip Code
Yu, Chun I; Becker, Christian; Metang, Patrick et al. (2014) Human CD141+ dendritic cells induce CD4+ T cells to produce type 2 cytokines. J Immunol 193:4335-43
Banchereau, Romain; Baldwin, Nicole; Cepika, Alma-Martina et al. (2014) Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines. Nat Commun 5:5283
Chaussabel, Damien; Baldwin, Nicole (2014) Democratizing systems immunology with modular transcriptional repertoire analyses. Nat Rev Immunol 14:271-80
Rajsbaum, Ricardo; Garcia-Sastre, Adolfo; Versteeg, Gijs A (2014) TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol 426:1265-84
Cao, Raquel G; Suarez, Nicolas M; Obermoser, Gerlinde et al. (2014) Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children. J Infect Dis 210:224-33
Schotsaert, Michael; GarcĂ­a-Sastre, Adolfo (2014) Influenza vaccines: a moving interdisciplinary field. Viruses 6:3809-26
Alsina, Laia; Israelsson, Elisabeth; Altman, Matthew C et al. (2014) A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4. Nat Immunol 15:1134-42
Ovsyannikova, Inna G; White, Sarah J; Albrecht, Randy A et al. (2014) Turkey versus guinea pig red blood cells: hemagglutination differences alter hemagglutination inhibition responses against influenza A/H1N1. Viral Immunol 27:174-8
Li, Lily; Lin, Marvin; Krassilnikova, Maria et al. (2014) Effect of cholecalciferol supplementation on inflammation and cellular alloimmunity in hemodialysis patients: data from a randomized controlled pilot trial. PLoS One 9:e109998
Tsang, John S; Schwartzberg, Pamela L; Kotliarov, Yuri et al. (2014) Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell 157:499-513

Showing the most recent 10 out of 33 publications