The purpose of the SHIMR Pilot Project Core is to support investigators with novel ideas or technologies relevant to the priority research topics in human immunology in the RFA-AI-09-040. These small grants will provide funds to obtain pilot data as a foundation for subsequent application for extramural funding.
The specific aims of this Core are: 1 A. to solicit pilot project proposals on an annual basis within the Stanford research community, 1 .B. to review these proposals and to forward requests for funding for 1-3 projects/year to the Steering Committee, 1 .C. to provide infrastructure support for the Pilot Projects during the award period, and 1 .D. to monitor the progress of the Pilot Projects on a quarterly basis as well as the overall success of the program by tracking publications and extramural funding obtained on the basis of these awards.

Public Health Relevance

We wish to analyze different disease/vaccine models in order to define common and unique characterstics of responder and non-responder individuals. We will develop new informative tools and assays that should illuminate specific questions regarding these study groups and will also be of benefit generally with respect to

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI090019-05
Application #
8705369
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
City
Stanford
State
CA
Country
United States
Zip Code
94304
Lee, Jung-Rok; Haddon, D James; Wand, Hannah E et al. (2016) Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus. Sci Rep 6:27623
Kidd, Marie J; Jackson, Katherine J L; Boyd, Scott D et al. (2016) DJ Pairing during VDJ Recombination Shows Positional Biases That Vary among Individuals with Differing IGHD Locus Immunogenotypes. J Immunol 196:1158-64
Fang, Fengqin; Yu, Mingcan; Cavanagh, Mary M et al. (2016) Expression of CD39 on Activated T Cells Impairs their Survival in Older Individuals. Cell Rep 14:1218-31
Looney, Timothy J; Lee, Ji-Yeun; Roskin, Krishna M et al. (2016) Human B-cell isotype switching origins of IgE. J Allergy Clin Immunol 137:579-586.e7
Su, Laura F; Del Alcazar, Daniel; Stelekati, Erietta et al. (2016) Antigen exposure shapes the ratio between antigen-specific Tregs and conventional T cells in human peripheral blood. Proc Natl Acad Sci U S A 113:E6192-E6198
Lund, Peder J; Elias, Joshua E; Davis, Mark M (2016) Global Analysis of O-GlcNAc Glycoproteins in Activated Human T Cells. J Immunol 197:3086-3098
Nair, N; Newell, E W; Vollmers, C et al. (2016) High-dimensional immune profiling of total and rotavirus VP6-specific intestinal and circulating B cells by mass cytometry. Mucosal Immunol 9:68-82
Finak, Greg; Langweiler, Marc; Jaimes, Maria et al. (2016) Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium. Sci Rep 6:20686
Rubelt, Florian; Bolen, Christopher R; McGuire, Helen M et al. (2016) Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells. Nat Commun 7:11112
Pan, Junliang; Dinh, Thanh Theresa; Rajaraman, Anusha et al. (2016) Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo. Blood 128:104-9

Showing the most recent 10 out of 106 publications