The major objectives of the Administrative Core are to establish a structure/mechanism to foster interactions, monitor progress, and promote the overall success of the Center for Systems Vaccinology, which will be funded by the present U19 grant application. To achieve these objectives, we will establish an Operations Office, which will be responsible for carrying out the following activities/functions at the Center: ? Facilitate and promote scientific interactions among all the investigators ? Provide support in the form of fiscal oversight ? Ensure that deadlines for progress reports and other research communications are met ? Protect intellectual property rights of individual investigators within the Center and execute material transfer agreements ? Conduct monthly, and annual meetings, journal club, seminars and symposia ? Evaluate the Center's goals and objectives, with a new research focus, if required, consistent with the mandate of the Center ? Manage data and devise a plan for sharing data among the investigators within and outside the Center ? Establish links with other Centers that are funded by the present U19 RFA To fulfill another important mandate of the Center, we will set up an External Scientific Advisory Group, composed of accomplished immunologists, vaccinologists and systems biologists, and seek their expert opinion and critical insights, with the goal of enhancing the scope and impact of our program. Taken together, the Administrative Core is organized to achieve a high degree of synergy and success by providing tools and mechanisms for effective interactions among the investigators and their programs at the Center and across other centers in the US.
To promote effective coordination and cooperation between the research projects and cores, to facilitate the timely achievement of the milestones established by each component, and to ensure the overall success of the Center's research goals and objectives.
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|Pulendran, Bali (2014) Systems vaccinology: probing humanity's diverse immune systems with vaccines. Proc Natl Acad Sci U S A 111:12300-6|
|Janssens, Sophie; Pulendran, Bali; Lambrecht, Bart N (2014) Emerging functions of the unfolded protein response in immunity. Nat Immunol 15:910-9|
|Tan, Yan; Tamayo, Pablo; Nakaya, Helder et al. (2014) Gene signatures related to B-cell proliferation predict influenza vaccine-induced antibody response. Eur J Immunol 44:285-95|
|Kwissa, Marcin; Nakaya, Helder I; Onlamoon, Nattawat et al. (2014) Dengue virus infection induces expansion of a CD14(+)CD16(+) monocyte population that stimulates plasmablast differentiation. Cell Host Microbe 16:115-27|
|Chiu, Christopher; McCausland, Megan; Sidney, John et al. (2014) Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV. PLoS Pathog 10:e1004008|
|Cortese, Mario; Sinclair, Charles; Pulendran, Bali (2014) Translating glycolytic metabolism to innate immunity in dendritic cells. Cell Metab 19:737-9|
|Oh, Jason Z; Ravindran, Rajesh; Chassaing, Benoit et al. (2014) TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity 41:478-92|
|Yu, Tianwei; Jones, Dean P (2014) Improving peak detection in high-resolution LC/MS metabolomics data using preexisting knowledge and machine learning approach. Bioinformatics 30:2941-8|
|Ravindran, Rajesh; Khan, Nooruddin; Nakaya, Helder I et al. (2014) Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science 343:313-7|
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