The Administrative Core of the Program Project will be responsible for supervising and coordinating all activities of the Program Project investigators and staff. Dr. Vincent Young will lead the Core while Ann Murphy will provide program administrative and financial support for the Program Project. An important function ofthe Administrative Core will be to link Program Project faculty in synergistic research to facilitate collaboration. The Administrative Core will also be responsible for managing all budgetary aspects ofthe Program Project and for interactions with NIAID staff. The Core will ensure that all Program Project publications are deposited in the NIH repository. The Administrative Core will interface with an External Advisory Board as well and coordinate annual visits by the External Advisors to review the progress of the Program Project. The specific proposed functions ofthe Administrative Core are to: 1. To provide leadership for the overall administration, coordination, and management of the Center. 2. To foster productive and collaborative research between all investigators on all projects. 3. To facilitate and coordinate data sharing/analysis and communications for all Center supported projects. 4. To establish a well-planned structure for the administrative staff;to ensure proper training and experience is in place. 5. To oversee the fiscal management of all Center activities 6. To interface with the ERIN Network Committee and other outside scientific and medical stakeholders. 7. To manage and oversee the Research Pilot Projects Plan. The Administrative Core will serve an essential function to fie the projects together administratively, coordinate the deposition of Program Project publications in the NIH repository, and to interface with an External Advisory Committee

Public Health Relevance

The Administrative Core program is responsible for the overall supervision and coordination of the University of Michigan ERIN CRC. The Administrative Core will provide program administrative and financial management for the Center. The Core will also provide integrated and coordinated data curation, storage, and analysis. The Pilot Project Program ofthe Center will be managed by the Core and external communication with NIH and other Centers will be coordinated by the Administrative Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI090871-04
Application #
8508843
Study Section
Special Emphasis Panel (ZAI1-BLG-M)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$212,439
Indirect Cost
$75,822
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Kopliku, Fatos A; Schubert, Alyxandria M; Mogle, Jill et al. (2015) Low prevalence of Clostridium septicum fecal carriage in an adult population. Anaerobe 32:34-6
Leslie, Jhansi L; Young, Vincent B (2015) The rest of the story: the microbiome and gastrointestinal infections. Curr Opin Microbiol 23:121-5
Seekatz, Anna M; Young, Vincent B (2014) Clostridium difficile and the microbiota. J Clin Invest 124:4182-9
Islam, J; Taylor, A L; Rao, K et al. (2014) The role of the humoral immune response to Clostridium difficile toxins A and B in susceptibility to C. difficile infection: a case-control study. Anaerobe 27:82-6
Rao, Krishna; Young, Vincent B; Aronoff, David M (2014) Fecal microbiota therapy: ready for prime time? Infect Control Hosp Epidemiol 35:28-30
Theriot, Casey M; Koenigsknecht, Mark J; Carlson Jr, Paul E et al. (2014) Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection. Nat Commun 5:3114
El-Zaatari, Mohamad; Chang, Yu-Ming; Zhang, Min et al. (2014) Tryptophan catabolism restricts IFN-?-expressing neutrophils and Clostridium difficile immunopathology. J Immunol 193:807-16
Huang, A M; Marini, B L; Frame, D et al. (2014) Risk factors for recurrent Clostridium difficile infection in hematopoietic stem cell transplant recipients. Transpl Infect Dis 16:744-50
Schloss, Patrick D; Iverson, Kathryn D; Petrosino, Joseph F et al. (2014) The dynamics of a family's gut microbiota reveal variations on a theme. Microbiome 2:25
Marino, Simeone; Baxter, Nielson T; Huffnagle, Gary B et al. (2014) Mathematical modeling of primary succession of murine intestinal microbiota. Proc Natl Acad Sci U S A 111:439-44

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