The Michigan State University Enterics Research Investigational Network, Cooperative Research Center (MSU ERIN CRC) is a multidisciplinary, highly integrated Research Center to study the enteric microbiome in health and disease to understand and alleviate diarrheal illness. The ERIN Center will be organized around three cross-cutting research thematic areas consisting of: Research Area 1-Microbial Ecology: Elucidating the role of the intestinal microbiota in pathogen resistance;Research Area 2 -Host Response: Campylobacter jejuni-mediated autoimmune neuropathies in (Hu) microbiota mouse models;and Research Area 3-Clinical Research: The impact of microbiome composition, diversity and function on enteric disease. The PI of MSU-ERIN Center is Dr. Linda Mansfield who will also serve as its Administrative Core Leader;the Core Leader Fiscal Administrator and Core Coordinator will be Ms. Margaret Nicholas;together they will form the Administrative Core Team (ACT). An internal advisory committee consisting of the Research Area Leadership will advise the PI on research matters. An External Science Advisory/ Committee made up of senior experts in the three fields covered by the research plan microbial ecology, host response/ immunology, and human clinical research/diagnostics will act in an advisory and steering capacity;the committee will guide the MSU ERIN CRC, keep it on track for research progress and goals, and help to maintain program integrity. The ACT will be responsible for coordinating the research efforts of the three proposed thematic areas, establishing and maintaining research quality, productivity and excellence, and ensuring the delivery of ERIN aims and objectives in a fimely fashion;the ACT will also serve a central communications and management function uniting all research projects under one administrative umbrella. The Local Executive Committee (LEC) will be the decision making body for the MSU ERIN CRC. It will consist of the PI, leaders of three thematic research areas, designated individual investigators for theme balance, and the Core Leader Fiscal Administrative &Core Coordinator;the LEC will assist with all aspects of ERIN: scientific, financial, and administrative. Thus, the organizational structure of the MSU ERIN-CRC consists of the Administrative Core and the Research Area Leadership, which together forms the Local Executive Committee (LEC). and the three Research Area Teams. The All ERIN group is the entire Internal Research Team only excluding the External Science Advisory Committee. The cross-functional structure of the ERIN-CRC has been so designed as to facilitate communication and interactive group research and to promote synergy, innovation, and continuous improvement.
This organizational structure is designed to keep MSU ERIN CRC member laboratories working together producfively to meet the goals of the research on schedule according to the Timeline. A similar structure has served the MSU NIH Food and Waterborne Diseases Integrated Research Network Microbiology Research Unit (MRU) well in this regard, and members of the MRU will bring their experience to the MSU ERIN CRC. These interactions will generate new ideas and enable faster progress than could othenwise be achieved.
|Sambanthamoorthy, Karthik; Luo, Chunyuan; Pattabiraman, Nagarajan et al. (2014) Identification of small molecules inhibiting diguanylate cyclases to control bacterial biofilm development. Biofouling 30:17-28|
|Jensen, Hanne; Roos, Stefan; Jonsson, Hans et al. (2014) Role of Lactobacillus reuteri cell and mucus-binding protein A (CmbA) in adhesion to intestinal epithelial cells and mucus in vitro. Microbiology 160:671-81|
|Tseng, Marion; Fratamico, Pina M; Manning, Shannon D et al. (2014) Shiga toxin-producing Escherichia coli in swine: the public health perspective. Anim Health Res Rev 15:63-75|
|Koestler, Benjamin J; Waters, Christopher M (2014) Bile acids and bicarbonate inversely regulate intracellular cyclic di-GMP in Vibrio cholerae. Infect Immun 82:3002-14|
|Britton, Robert A; Young, Vincent B (2014) Role of the intestinal microbiota in resistance to colonization by Clostridium difficile. Gastroenterology 146:1547-53|
|Koestler, Benjamin J; Seregin, Sergey S; Rastall, David P W et al. (2014) Stimulation of innate immunity by in vivo cyclic di-GMP synthesis using adenovirus. Clin Vaccine Immunol 21:1550-9|
|Robinson, Catherine D; Auchtung, Jennifer M; Collins, James et al. (2014) Epidemic Clostridium difficile strains demonstrate increased competitive fitness compared to nonepidemic isolates. Infect Immun 82:2815-25|
|Britton, Robert A; Irwin, Regina; Quach, Darin et al. (2014) Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J Cell Physiol 229:1822-30|
|Malik, A; Sharma, D; St Charles, J et al. (2014) Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity. Mucosal Immunol 7:802-17|
|Hunter, Jessica L; Severin, Geoffrey B; Koestler, Benjamin J et al. (2014) The Vibrio cholerae diguanylate cyclase VCA0965 has an AGDEF active site and synthesizes cyclic di-GMP. BMC Microbiol 14:22|
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