Since HIV persists within an individual once it has established infection, an arms race between host response and virus evasion takes place throughout the natural history of infection. By investigating the dynamics of the host immune response over time and how the virus adapts to evade it, we seek to identify genetic and structural features of potent immunogens. The response elicited by such immunogens may be unable to eradicate an established infection, but may protect individuals from becoming infected. We, therefore, propose to investigate how the analysis of viral evolution (eg. point mutation, insertions and deletions (indels) and recombination) during viral evasion from broad and potent NAb activity may reveal those viral genetic elements that elicit strong immune responses.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI090970-05
Application #
8721323
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
International AIDS Vaccine Initiative
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
Karris, Maile Y; Umlauf, Anya; Vaida, Florin et al. (2016) A randomized controlled clinical trial on the impact of CCR5 blockade with maraviroc in early infection on T-cell dynamics. Medicine (Baltimore) 95:e5315
Krumm, Stefanie A; Mohammed, Hajer; Le, Khoa M et al. (2016) Mechanisms of escape from the PGT128 family of anti-HIV broadly neutralizing antibodies. Retrovirology 13:8
MacLeod, Daniel T; Choi, Nancy M; Briney, Bryan et al. (2016) Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch. Immunity 44:1215-26
Landais, Elise; Huang, Xiayu; Havenar-Daughton, Colin et al. (2016) Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort. PLoS Pathog 12:e1005369
Var, Susanna R; Day, Tyler R C; Vitomirov, Andrej et al. (2016) Mitochondrial injury and cognitive function in HIV infection and methamphetamine use. AIDS 30:839-48
Doores, Katie J; Kong, Leopold; Krumm, Stefanie A et al. (2015) Two classes of broadly neutralizing antibodies within a single lineage directed to the high-mannose patch of HIV envelope. J Virol 89:1105-18
Shah, Kartik A; Clark, John J; Goods, Brittany A et al. (2015) Automated pipeline for rapid production and screening of HIV-specific monoclonal antibodies using pichia pastoris. Biotechnol Bioeng 112:2624-9
Frost, Simon D W; Murrell, Ben; Hossain, A S Md Mukarram et al. (2015) Assigning and visualizing germline genes in antibody repertoires. Philos Trans R Soc Lond B Biol Sci 370:
Murrell, Ben; Weaver, Steven; Smith, Martin D et al. (2015) Gene-wide identification of episodic selection. Mol Biol Evol 32:1365-71
Ozkumur, Ayca Yalcin; Goods, Brittany A; Love, J Christopher (2015) Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning. Small 11:4643-50

Showing the most recent 10 out of 40 publications