The University of Rochester was fortunate to be one of the successful applicants following the original RFA in 2005, and became one of the eight Centers for Medical Countermeasures against Radiafion that make up the current CMCR network: the Center for Biophysical Assessment and Risk Management following Irradiation (CBARMFI). As has been demonstrated to date, the Administrative Core will maintain the UofRCMCR's responsibilities regarding National Institute of Allergy and Infectious Diseases (NIAID) programmatic issues and goals, and will facilitate actions within the Center when deemed appropriate. The U of R's Administrative Core has provided leadership within the CMCR network, including the planning and organizing of national, network, and open meetings and workshops and will continue to contribute significantly to the leadership and funcfioning of the CMCR National Network of Centers, as well as to the national reputation and development of the CMCR program. The Administrative Core facilitates oversight and evaluation of progress through development of documentation for Project Leaders and External Scientific Advisors regarding stated goals, milestones and timelines, comparability of experimental results, etc. Our PI, Dr. Williams, will work closely with her financial team (Brian Martin and Amber Bessette) through monthly meetings so as to maintain strict budgetary oversight. Annual meetings/retreats of the UofR-CMCR group with its External Scientific Advisory Group (ESAG), which will be arranged prior to submission of the required Progress Reports, will overview progress and provide direction for each subsequent year. Finally, since all of the projects will require services from members of the office of Radiation Safety (e.g., assistance with security, dosimetric measurements, storage of radioactive materials, training of personnel, and removal of contaminated animal bedding), the University of Rochester's Radiation Safety Officer, Dr. Tom Morgan, together with a member of his team, will join the Administrative Core in order to provide coordinated services and centralize the administrative and financial requirements.

Public Health Relevance

We understand that the ultimate purpose of the government's investment in this research is to enable personal and societal recovery following a radiation terrorism incident or a nuclear event. Indeed, our Administrative Core makes research into Federal policy statements and the emergency response literature one of its many priorities. Core A personnel work to ensure that all CMCR personnel are equipped with the most current and widely accepted information regarding radiation exposure and health risks developed in conjunction with NIAID and other federal officials and based upon published Government information (e.g., REMM database, CDC, ORISE, etc.).

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI091036-03
Application #
8381736
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$446,511
Indirect Cost
$114,447
Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
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Domingo-Gonzalez, Racquel; Das, Shibali; Griffiths, Kristin L et al. (2017) Interleukin-17 limits hypoxia-inducible factor 1? and development of hypoxic granulomas during tuberculosis. JCI Insight 2:
Sweet, Tara B; Hurley, Sean D; Wu, Michael D et al. (2016) Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation. Radiat Res 186:614-623
Moravan, Michael J; Olschowka, John A; Williams, Jacqueline P et al. (2016) Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling. J Neuroinflammation 13:30
Begolly, Sage; Shrager, Peter G; Olschowka, John A et al. (2016) Fractionation Spares Mice From Radiation-Induced Reductions in Weight Gain But Does Not Prevent Late Oligodendrocyte Lineage Side Effects. Int J Radiat Oncol Biol Phys 96:449-457
Groves, Angela M; Johnston, Carl J; Misra, Ravi S et al. (2016) Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation. Int J Radiat Biol 92:754-765
Rabender, Christopher; Mezzaroma, Eleonora; Mauro, Adolfo G et al. (2016) IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects. Radiat Res 186:478-488
Williams, Jacqueline P; Calvi, Laura; Chakkalakal, Joe V et al. (2016) Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury. Radiat Res 186:1-16
Barlow, Margaret L; Cummings, Ryan J; Pentland, Alice P et al. (2016) Total-Body Irradiation Exacerbates Dissemination of Cutaneous Candida Albicans Infection. Radiat Res 186:436-446

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