The Pilot Research Project Program for the University of Rochester's Center for Medical Countermeasures against Radiation (CMCR) is designed to identify and fund innovative pilot studies in radiation-related research, with an emphasis on the basic science supporting drug development to counter injuries that would result from a radiological dispersal device (RDD) or a nuclear detonation. These pilot projects are solicited from Institutions both within and outside of the CMCR Network through several approaches, including direct email solicitation and online announcement by the Radiafion Research Society (RRS) to its full membership, as well as announcement on both the UR CMCR website and the national NIH/NIAID/CMCR website. As an indication of the breadth of our announcement efforts and the diversity of applications we attract, over the course of the previous funding period the UR CMCR received a total of 74 applications from 32 institutions worldwide (including from Canada. China, France. Israel, and Japan).

Public Health Relevance

As we continue on with our Pilot program, we will build upon Its real scientific success: our current Center application is the product of mature collaborations with our Pilot awardees. Our new Center has as its anchor the continuation of the CBARMFI Lung Toxicity and Inhalation research (Jacob Finkelstein and Jacqueline Williams-Project 1), while the remaining Projects were originally nurtured by our CBARMFI Pilot Research Program 2005-2010;indeed, Drs. Kerry O'Banion and John Olschowka (Project 2-Brain), Edith Lord and Julie Ryan (Project 3-Skin and Immunology), and James Palis (Project 4-Bone Marrow) were an CBARMFI Pilot award recipients. These investigators have been sharing tissues and data, discussing experimental design, and serving as mutual scientific advisors for several years as part of their work in CBARMFI: the true nature of collaboration.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI091036-05
Application #
8705380
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
DUNS #
City
Rochester
State
NY
Country
United States
Zip Code
14627
Begolly, Sage; Olschowka, John A; Love, Tanzy et al. (2018) Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion. Glia 66:846-861
Dunlap, Micah D; Howard, Nicole; Das, Shibali et al. (2018) A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis. Mucosal Immunol 11:1727-1742
Howard, Nicole C; Marin, Nancy D; Ahmed, Mushtaq et al. (2018) Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes. Nat Microbiol 3:1099-1108
Groves, Angela M; Johnston, Carl J; Williams, Jacqueline P et al. (2018) Role of Infiltrating Monocytes in the Development of Radiation-Induced Pulmonary Fibrosis. Radiat Res 189:300-311
Beach, Tyler A; Johnston, Carl J; Groves, Angela M et al. (2017) Radiation induced pulmonary fibrosis as a model of progressive fibrosis: Contributions of DNA damage, inflammatory response and cellular senescence genes. Exp Lung Res 43:134-149
Domingo-Gonzalez, Racquel; Das, Shibali; Griffiths, Kristin L et al. (2017) Interleukin-17 limits hypoxia-inducible factor 1? and development of hypoxic granulomas during tuberculosis. JCI Insight 2:
Judge, Jennifer L; Lacy, Shannon H; Ku, Wei-Yao et al. (2017) The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis. Radiat Res 188:35-43
Groves, Angela M; Johnston, Carl J; Misra, Ravi S et al. (2016) Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation. Int J Radiat Biol 92:754-765
Williams, Jacqueline P; Calvi, Laura; Chakkalakal, Joe V et al. (2016) Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury. Radiat Res 186:1-16
Griffiths, Kristin L; Ahmed, Mushtaq; Das, Shibali et al. (2016) Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun 7:13894

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