The Pilot Research Project Program for the University of Rochester's Center for Medical Countermeasures against Radiation (CMCR) is designed to identify and fund innovative pilot studies in radiation-related research, with an emphasis on the basic science supporting drug development to counter injuries that would result from a radiological dispersal device (RDD) or a nuclear detonation. These pilot projects are solicited from Institutions both within and outside of the CMCR Network through several approaches, including direct email solicitation and online announcement by the Radiafion Research Society (RRS) to its full membership, as well as announcement on both the UR CMCR website and the national NIH/NIAID/CMCR website. As an indication of the breadth of our announcement efforts and the diversity of applications we attract, over the course of the previous funding period the UR CMCR received a total of 74 applications from 32 institutions worldwide (including from Canada. China, France. Israel, and Japan).

Public Health Relevance

As we continue on with our Pilot program, we will build upon Its real scientific success: our current Center application is the product of mature collaborations with our Pilot awardees. Our new Center has as its anchor the continuation of the CBARMFI Lung Toxicity and Inhalation research (Jacob Finkelstein and Jacqueline Williams-Project 1), while the remaining Projects were originally nurtured by our CBARMFI Pilot Research Program 2005-2010;indeed, Drs. Kerry O'Banion and John Olschowka (Project 2-Brain), Edith Lord and Julie Ryan (Project 3-Skin and Immunology), and James Palis (Project 4-Bone Marrow) were an CBARMFI Pilot award recipients. These investigators have been sharing tissues and data, discussing experimental design, and serving as mutual scientific advisors for several years as part of their work in CBARMFI: the true nature of collaboration.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
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University of Rochester
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Evans, Andrew G; Calvi, Laura M (2015) Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis. Ann N Y Acad Sci 1335:63-77
Frisch, Benjamin J; Calvi, Laura M (2014) Hematopoietic stem cell cultures and assays. Methods Mol Biol 1130:315-24
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Gopal, Radha; Rangel-Moreno, Javier; Fallert Junecko, Beth A et al. (2014) Mucosal pre-exposure to Th17-inducing adjuvants exacerbates pathology after influenza infection. Am J Pathol 184:55-63
Gao, Feng; Fish, Brian L; Szabo, Aniko et al. (2014) Enhanced survival from radiation pneumonitis by combined irradiation to the skin. Int J Radiat Biol 90:753-61
O'Banion, M Kerry (2014) Does peripheral inflammation contribute to Alzheimer disease? Evidence from animal models. Neurology 83:480-1
Hoffman, Corey M; Calvi, Laura M (2014) Minireview: complexity of hematopoietic stem cell regulation in the bone marrow microenvironment. Mol Endocrinol 28:1592-601
Cherry, Jonathan D; Olschowka, John A; O'Banion, M Kerry (2014) Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation 11:98
Gopal, Radha; Monin, Leticia; Slight, Samantha et al. (2014) Unexpected role for IL-17 in protective immunity against hypervirulent Mycobacterium tuberculosis HN878 infection. PLoS Pathog 10:e1004099
Gopal, Radha; Monin, Leticia; Torres, Diana et al. (2013) S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. Am J Respir Crit Care Med 188:1137-46

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