This core will have a critically important role in all 3 projects, providing access to a population of pafients that provide a unique opportunity to develop the techniques and test the instrumentafion that is being developed. One of the potentially limiting factors in the development of accurate and effecfive biodosimetry for triage of large populations potenfially exposed to clinically significant levels of ionizing radiafion has been the lack of suitable samples and subjects to test the validity ofthe assays and to facilitate the development of the techniques. Suitable samples/subjects require exposure to ionizing radiation in the dose range leading to the acute radiation syndrome, (2 -12 Gy). It would be completely unethical to expose human individuals to such doses of radiation for the purpose of developing the methodology and evaluation in animal models is not pracfical or relevant at this stage of development. We can instead, however, utilize pafients who receive such radiafion exposures as part of their treatment for myelosuppression and immunosupression. The DFCI is one ofthe few places in the world where there are large numbers of patients who as a part of their therapy, receive TBI in the dose ranges that are direcfiy pertinent to the levels needed to be measured in the event of a radiafion exposure event. In addition, there are ongoing research programs at DFCI that are invesfigafing the effects of such irradiations and strategies to minimize the effects of the exposures. This provides a unique opportunity to carry out the much-needed development and validafion of a methodology designed to make such measurements as a means of facilitating an effecfive response to an event in which large numbers of people potenfially are exposed to clinically significant dose of ionizing radiafion. The personnel from the DFCI will work with the personnel from the projects to make measurements in the TBI patient populafion in vivo in teeth and nails. Clippings of nails also will be obtained for use by project 2. When the prototype instruments suitable for deployed use by non-expert personnel are constructed, measurements will be made at DFCI using members ofthe team that have not previously been involved with the operafion ofthe instruments, providing a realisfic test ofthe capabilifies ofthe design, with important feedback for improvement of the prototypes.

Public Health Relevance

This core will permit the developments of the biodosimetry techniques to be carried out with highly germane subjects, enabling the instruments that will be developed to be appropriate and effective for the intended use, for triage of large populations potentially exposed to clinically significant levels of ionizing radiation

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
United States
Zip Code
Rogan, Peter K; Li, Yanxin; Wickramasinghe, Asanka et al. (2014) Automating dicentric chromosome detection from cytogenetic biodosimetry data. Radiat Prot Dosimetry 159:95-104
Sidabras, Jason W; Varanasi, Shiv K; Mett, Richard R et al. (2014) A microwave resonator for limiting depth sensitivity for electron paramagnetic resonance spectroscopy of surfaces. Rev Sci Instrum 85:104707
Swartz, Harold M; Flood, Ann Barry; Williams, Benjamin B et al. (2014) Comparison of the needs for biodosimetry for large-scale radiation events for military versus civilian populations. Health Phys 106:755-63
Williams, Benjamin B; Flood, Ann Barry; Salikhov, Ildar et al. (2014) In vivo EPR tooth dosimetry for triage after a radiation event involving large populations. Radiat Environ Biophys 53:335-46
Ivannikov, Alexander I; Skvortsov, Valeri G; Stepanenko, Valeri F et al. (2014) Comparative analysis between radiation doses obtained by EPR dosimetry using tooth enamel and established analytical methods for the population of radioactively contaminated territories. Radiat Prot Dosimetry 159:125-9
Junwang, Guo; Qingquan, Yuan; Jianbo, Cong et al. (2014) New developed cylindrical TM010 mode EPR cavity for X-band in vivo tooth dosimetry. PLoS One 9:e106587
Flood, Ann Barry; Boyle, Holly K; Du, Gaixin et al. (2014) Advances in a framework to compare bio-dosimetry methods for triage in large-scale radiation events. Radiat Prot Dosimetry 159:77-86
Swartz, Harold M; Williams, Benjamin B; Zaki, Bassem I et al. (2014) Clinical EPR: unique opportunities and some challenges. Acad Radiol 21:197-206
He, Xiaoming; Swarts, Steven G; Demidenko, Eugene et al. (2014) Development and validation of an ex vivo electron paramagnetic resonance fingernail biodosimetric method. Radiat Prot Dosimetry 159:172-81
Swartz, Harold M; Williams, Benjamin B; Flood, Ann Barry (2014) Overview of the principles and practice of biodosimetry. Radiat Environ Biophys 53:221-32

Showing the most recent 10 out of 18 publications