The overall aim of this core is to provide sophisticated state of the art support for the instrumental developments needed to reach the goals of the Center. It will accomplish this in two closely related ways: 1) to support the instrumental advances, both hardware and software needed to advance each project 2) to ufilize the instrumental and procedural developments in each project to design, construct, and test the 3 types of prototype instruments that will carry out the measurements including being field-deployable and capable of being operated by non-expert personnel with no prior training. The work plan and accompanying budget has been developed to facilitate the capabilifies of this core carrying out its responsibilities for the overall project: to develop optimized critical components to advance the technology in all three projects and then to develop a prototype that incorporates the developments. The personnel in this core have specific responsibilifies that extend across all three projects and also incorporate concepts, software, and hardware within each project. The personnel in this core will be involved in the day to day operations of the three projects, especially in the development of the specialized instrumentation to facilitate each project. Because the fime commitments among the three projects will vary over time and among individuals in this core, it is most efficient to not to try to indicate a set proportion of their efforts for the three projects. Instead we will have the capability and the flexibility to provide the effort that is need to attain maximal progress in all 3 projects and will be able to advance more quickly projects where the field deployability can be achieved most rapidly. The direct project-supporting acfivities will be roughly 40% each for projects 1 and 3 (these are at Dartmouth) and 20% for Project 2 which is centered at Florida. During the course of the grant period the personnel in this core will be spending an increasing amount of their fime and effort in the design, construction, and testing ofthe prototype instruments to be produced. The personnel ofthe projects will be closely involved in both the design and the testing phases of the prototypes that are produced. This core will also interact closely with the Core at MCW where the latter will use their specialized expertise to provide components and advice that will enable the projects to move forward as effectively and efficienfiy as possible.

Public Health Relevance

This core will work closely with the projects in a synergistic way to advance all 3 projects at the maximum feasible rate, leading to the early development of effective prototype devices for making dosimetry measurements in a large population potenfially exposed to clinically significant levels of ionizing radiation. This will enable the medical response to as effective and efficient as possible after such an event.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI091173-04
Application #
8522146
Study Section
Special Emphasis Panel (ZAI1-KS-I)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
4
Fiscal Year
2013
Total Cost
$952,692
Indirect Cost
$270,248
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Rogan, Peter K; Li, Yanxin; Wickramasinghe, Asanka et al. (2014) Automating dicentric chromosome detection from cytogenetic biodosimetry data. Radiat Prot Dosimetry 159:95-104
Sidabras, Jason W; Varanasi, Shiv K; Mett, Richard R et al. (2014) A microwave resonator for limiting depth sensitivity for electron paramagnetic resonance spectroscopy of surfaces. Rev Sci Instrum 85:104707
Swartz, Harold M; Flood, Ann Barry; Williams, Benjamin B et al. (2014) Comparison of the needs for biodosimetry for large-scale radiation events for military versus civilian populations. Health Phys 106:755-63
Williams, Benjamin B; Flood, Ann Barry; Salikhov, Ildar et al. (2014) In vivo EPR tooth dosimetry for triage after a radiation event involving large populations. Radiat Environ Biophys 53:335-46
Ivannikov, Alexander I; Skvortsov, Valeri G; Stepanenko, Valeri F et al. (2014) Comparative analysis between radiation doses obtained by EPR dosimetry using tooth enamel and established analytical methods for the population of radioactively contaminated territories. Radiat Prot Dosimetry 159:125-9
Junwang, Guo; Qingquan, Yuan; Jianbo, Cong et al. (2014) New developed cylindrical TM010 mode EPR cavity for X-band in vivo tooth dosimetry. PLoS One 9:e106587
Flood, Ann Barry; Boyle, Holly K; Du, Gaixin et al. (2014) Advances in a framework to compare bio-dosimetry methods for triage in large-scale radiation events. Radiat Prot Dosimetry 159:77-86
Swartz, Harold M; Williams, Benjamin B; Zaki, Bassem I et al. (2014) Clinical EPR: unique opportunities and some challenges. Acad Radiol 21:197-206
He, Xiaoming; Swarts, Steven G; Demidenko, Eugene et al. (2014) Development and validation of an ex vivo electron paramagnetic resonance fingernail biodosimetric method. Radiat Prot Dosimetry 159:172-81
Swartz, Harold M; Williams, Benjamin B; Flood, Ann Barry (2014) Overview of the principles and practice of biodosimetry. Radiat Environ Biophys 53:221-32

Showing the most recent 10 out of 18 publications