CORE A: Given the size, complexity, duration, and scope involved. Core A will be fundamental in enabling the successful establishment and operation of the entire program. All costs for administrative support for the Cores and Projects are included here. Dr. Stokes Peebles will assume ultimate administrative responsibility for the management of this Core. Administrative, fiscal services, and clerical support for the entire program will be shared by all Project Leaders, Core Leaders and Co-Investigators. This Core will provide and maintain all of the administrative space and functions for the entire program, including but not limited to, offices for all investigators, an administrative area with secretarial and administrative support, a copy/work room, and a conference room with up to date audiovisual amenities. Administrative functions will include ordering of supplies and equipment, maintenance of all records, keeping and monitoring of budgets, maintenance of the personnel database for grant effort, interactions with University administrative offices and the NIH regarding budgetary and other administrative matters, and scheduling and organizing meetings and presentations. This Core will support all of the computer hardware and software resources for the administrative and clerical functions of the program. This Core will coordinate and support the activities of the Internal Advisory Committee and the External Scientific Advisory Board. The basic functions and objectives of the Core include: quality management of program resources, integration of the program, oversight of deliverables within the timeframe, assistance with data management, and leading the vision. To achieve these objectives, detailed plans are presented for administrative structure and leadership, project management, external Scientific Advisory Board, and communication/meetings.
RSV is the leading cause of bronchiolitis and causes >100,000 infant hopsitalizations in the US each year. Studies have also revealed that severe RSV infection in infancy is associated with the later development of childhood asthma. This application will examine both host genetic and immune response determinants, as well as the influence of specific RSV strains, on severity of RSV bronchiolitis and childhood asthma. In addition, we will define the role of a novel therapeutic target, PGI2, in RSV pathogenesis.
|Turi, Kedir N; Romick-Rosendale, Lindsey; Ryckman, Kelli K et al. (2017) A review of metabolomics approaches and their application in identifying causal pathways of childhood asthma. J Allergy Clin Immunol :|
|Rajan, Devi; Chinnadurai, Raghavan; Keefe, Evan O et al. (2017) Protective role of Indoleamine 2,3 dioxygenase in Respiratory Syncytial Virus associated immune response in airway epithelial cells. Virology 512:144-150|
|Cephus, Jacqueline-Yvonne; Stier, Matthew T; Fuseini, Hubaida et al. (2017) Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation. Cell Rep 21:2487-2499|
|Stier, Matthew T; Goleniewska, Kasia; Cephus, Jacqueline Y et al. (2017) STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection. J Immunol 199:510-519|
|Johnston, Henry Richard; Hu, Yi-Juan; Gao, Jingjing et al. (2017) Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome. Sci Rep 7:46398|
|Rosas-Salazar, Christian; Hartert, Tina V (2017) Prenatal exposures and the development of childhood wheezing illnesses. Curr Opin Allergy Clin Immunol 17:110-115|
|Chatterjee, Srirupa; Luthra, Priya; Esaulova, Ekaterina et al. (2017) Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses. Nat Microbiol 2:17101|
|Boyoglu-Barnum, S; Todd, S O; Meng, J et al. (2017) Mutating the CX3C Motif in the G Protein Should Make a Live Respiratory Syncytial Virus Vaccine Safer and More Effective. J Virol 91:|
|Zhou, Weisong; Zhang, Jian; Goleniewska, Kasia et al. (2016) Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung Inflammation. J Immunol 197:1577-86|
|Bloodworth, Melissa H; Newcomb, Dawn C; Dulek, Daniel E et al. (2016) STAT6 Signaling Attenuates Interleukin-17-Producing ?? T Cells during Acute Klebsiella pneumoniae Infection. Infect Immun 84:1548-55|
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