This Administration Core will provide the AADCRC Program with the management, coordination and supervision required for successful completion of the Program at the highest level. Our AADCRC proposal brings together several leading asthma investigators in a multi-project, multi-core application to focus on important questions in asthma pathophysiology. To meet this challenge, we have three co-principal investigators (co-PIs), Dr. Steve White, Dr. Carole Ober, and Dr. Jerry Krishnan. There are also six Co-Investigators (Co-Is) who provide additional depth and breadth of asthma expertise, as well as access to large numbers of patients with asthma. The grouping of three separate projects and four core services requires a strong administrative core to ensure the goals of the Program are realized. The Administration Core will provide administrative services for all projects and cores, including financial management and fiscal oversight, communications management including educational opportunities, and services for the Program Steering Committee. The chief administrator will assist the core director in providing these services.
| Stein, Michelle M; Thompson, Emma E; Schoettler, Nathan et al. (2018) A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol 142:749-764.e3 |
| Hrusch, C L; Manns, S T; Bryazka, D et al. (2018) ICOS protects against mortality from acute lung injury through activation of IL-5+ ILC2s. Mucosal Immunol 11:61-70 |
| Ober, Carole; Sperling, Anne I; von Mutius, Erika et al. (2017) Immune development and environment: lessons from Amish and Hutterite children. Curr Opin Immunol 48:51-60 |
| White, Steven R; Nicodemus-Johnson, Jessie; Laxman, Bharathi et al. (2017) Elevated levels of soluble humanleukocyte antigen-G in the airways are a marker for a low-inflammatory endotype of asthma. J Allergy Clin Immunol 140:857-860 |
| Press, Valerie G; Kelly, Colleen A; Kim, John J et al. (2017) Virtual Teach-To-Goal™ Adaptive Learning of Inhaler Technique for Inpatients with Asthma or COPD. J Allergy Clin Immunol Pract 5:1032-1039.e1 |
| Krishack, Paulette A; Wang, Kanix; Rzhetsky, Andrey et al. (2017) Preexisting Type 2 Immune Activation Protects against the Development of Sepsis. Am J Respir Cell Mol Biol 57:628-630 |
| Narayanamurthy, Vaishnavi; Sweetnam, John M; Denner, Darcy R et al. (2017) The metabolic footprint of the airway bacterial community in cystic fibrosis. Microbiome 5:67 |
| Johnston, Henry Richard; Hu, Yi-Juan; Gao, Jingjing et al. (2017) Identifying tagging SNPs for African specific genetic variation from the African Diaspora Genome. Sci Rep 7:46398 |
| Igartua, Catherine; Davenport, Emily R; Gilad, Yoav et al. (2017) Host genetic variation in mucosal immunity pathways influences the upper airway microbiome. Microbiome 5:16 |
| Ober, Carole (2016) Asthma Genetics in the Post-GWAS Era. Ann Am Thorac Soc 13 Suppl 1:S85-90 |
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