While highly active antiretroviral therapy remains one of the great triumphs of HIV/AIDS research and has resulted in a significant decrease in morbidity and mortality, it requires life-long adherence and is associated with significant toxicities and cost. Antiretroviral therapy alone cannot eradicate HIV;accordingly, new approaches are required to understand the mechanisms by which HIV persists during therapy and to identify interventions that can eradicate the virus from the body of an infected person. We have established an international Collaboratory of academic and industry investigators who have a long and successful track record of collaborating with others to conceive, implement, and complete innovative research projects relevant to characterizing viral persistence and exploring interventions to eradicate the virus. The Administrative Core will ensure that the scientific vision that unifies the Collaboratory is enacted in all the projects and cores, and reflected in the research that is produced. The Core's functions are especially important because our Collaboratory integrates researchers across several international locations as well as multiple institutions within the United States.
The specific aims of the Administrative Core are: 1) to provide an organizational and programmatic structure;2) to provide organizational and financial oversight and planning, set priorities, and establish a decision-making process;3) to ensure efficient data, information and resource sharing;and 4) to establish a mechanism for expanding the current Collaboratory.
These aims will be achieved by employing a range of technologies to support regular, efficient communications and information sharing between the steering committee, executive committee, Scientific Advisory Panel, and all participants in the Collaboratory. The methodologies proposed here will maximize the productive participation of all members of the Collaboratory and provide a platform on which data gathered within projects and cores will inform the activities of other components of the Collaboratory.
We have established an international Collaboratory of academic and industry investigators who have a long and successful track record of collaborating with each other on research designed to undestand why HIV persists and how it can be eradicated from the body of an infected person. The Administrative Core will facilitate interactions between the investigators and support the planning, conduct, and evaluation of the Collaboratory's research activities.
|Tjiam, M Christian; Morshidi, Mazmah A; Sariputra, Lucy et al. (2017) Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57: 01 Is Only Observed in Viremic Controllers. J Acquir Immune Defic Syndr 76:e90-e92|
|Martin, Alyssa R; Pollack, Ross A; Capoferri, Adam et al. (2017) Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity. J Clin Invest 127:651-656|
|Power, Jennifer; Fileborn, Bianca; Dowsett, Gary W et al. (2017) HIV cure research: print and online media reporting in Australia. J Virus Erad 3:229-235|
|Winckelmann, Anni; Barton, Kirston; Hiener, Bonnie et al. (2017) Romidepsin-induced HIV-1 viremia during effective ART contains identical viral sequences with few deleterious mutations. AIDS :|
|Mota, Talia M; Rasmussen, Thomas A; Rhodes, Ajantha et al. (2017) No adverse safety or virological changes 2 years following vorinostat in HIV-infected individuals on antiretroviral therapy. AIDS 31:1137-1141|
|Rasmussen, Thomas A; Anderson, Jenny L; Wightman, Fiona et al. (2017) Cancer therapies in HIV cure research. Curr Opin HIV AIDS 12:96-104|
|Kaiser, Philipp; Joshi, Sunil K; Kim, Peggy et al. (2017) Assays for precise quantification of total (including short) and elongated HIV-1 transcripts. J Virol Methods 242:1-8|
|Symons, Jori; Chopra, Abha; Malatinkova, Eva et al. (2017) HIV integration sites in latently infected cell lines: evidence of ongoing replication. Retrovirology 14:2|
|Tauriainen, Johanna; Scharf, Lydia; Frederiksen, Juliet et al. (2017) Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals. Sci Rep 7:40354|
|Seang, Sophie; Somasunderam, Anoma; Nigalye, Maitreyee et al. (2017) Circulating LOXL2 Levels Reflect Severity of Intestinal Fibrosis and GALT CD4+ T Lymphocyte Depletion in Treated HIV Infection. Pathog Immun 2:239-252|
Showing the most recent 10 out of 158 publications