Understanding the cellular and tissue reservoirs of HIV-1 infection before and during H/ ART, and the responses in cell culture and animal models to therapies that reactivate viral gene expression in latently infected cells should enable design of therapies that ultimately aim to eradicate HIV-1 infection, In situ hybridization, in situ PCR, immunohistochemistry and combinations thereof will provide investigaors in the collaboratory with the tools to characterize cell and tissue reseroirs in the non-human primate model, and the response to therapies that induce reactivation in the animal model and cell culture model.

Public Health Relevance

Understanding the cellular and tissue reservoirs of HIV-1 infection before and during HAART, and the responses in cell culture and animal models to therapies that reactivate viral gene expression in latently infected cells should enable design of therapies that ultimately aim to eradicate HIV-1 infection.

Agency
National Institute of Health (NIH)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI096113-04
Application #
8707357
Study Section
Special Emphasis Panel (ZAI1)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
City
Chapel Hill
State
NC
Country
United States
Zip Code
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