The Clinical Core (Core D) will be a resource to provide peripheral blood for T cell studies from well characterized allergic rhinitis and asthma subjects to be used in each of the three projects comprising this LIAI U19 Program (Sette, Project 1;Peters, Project 2;Rao, Project 3), To allow the investigation of longitudinal changes in T cell responses in relation to allergen exposure, peripheral blood will be obtained at time points before, during and after the Timothy Grass (TG) pollen season in subjects with seasonal TG induced allergic rhinitis and asthma. In addition to obtaining blood during seasonal exposure to TG, blood will also be collected before and after TG nasal or inhalation allergen challenge in allergic rhinitis and asthma subjects. These studies will determine whether T cell/immune responses are similar or different in allergic rhinitis compared to asthma subjects sensitized to the same allergens. The influence of specific immunotherapy (SIT) with TG on T cell responses will be investigated by obtaining peripheral blood for study before institution of SIT and during the maintenance phase of SIT. These studies will provide insight into both the T cell responses induced by SIT, as well as determine whether there are differences in the T cell response in subjects who are, or are not, desensitized to TG pollen following SIT.

Public Health Relevance

An improved understanding of the immune response to common inhaled allergens such as grass pollen, dust mite, and cat allergens in subjects with sinus allergies and asthma will assist in identifying immune pathways that need to be dampened down to make such allergic patients not have symptoms on exposure to these allergens.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI100275-01
Application #
8325213
Study Section
Special Emphasis Panel (ZAI1-PA-I (J1))
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
1
Fiscal Year
2012
Total Cost
$346,039
Indirect Cost
$122,019
Name
La Jolla Institute
Department
Type
DUNS #
603880287
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Sette, Alessandro; Schulten, Véronique (2017) It's a lot of work to be nonallergic. J Allergy Clin Immunol 139:769-770
Schulten, Véronique; Tripple, Victoria; Seumois, Grégory et al. (2017) Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol :
Westernberg, Luise; Schulten, Véronique; Greenbaum, Jason A et al. (2016) T-cell epitope conservation across allergen species is a major determinant of immunogenicity. J Allergy Clin Immunol 138:571-578.e7
Schmiedel, Benjamin Joachim; Seumois, Grégory; Samaniego-Castruita, Daniela et al. (2016) 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells. Nat Commun 7:13426
Oseroff, Carla; Pham, John; Frazier, April et al. (2016) Immunodominance in allergic T-cell reactivity to Japanese cedar in different geographic cohorts. Ann Allergy Asthma Immunol 117:680-689.e1
Engel, Isaac; Seumois, Grégory; Chavez, Lukas et al. (2016) Innate-like functions of natural killer T cell subsets result from highly divergent gene programs. Nat Immunol 17:728-39
Pham, J; Oseroff, C; Hinz, D et al. (2016) Sequence conservation predicts T cell reactivity against ragweed allergens. Clin Exp Allergy 46:1194-205
Schulten, V; Tripple, V; Aasbjerg, K et al. (2016) Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy. Clin Exp Allergy 46:439-48
Seumois, Grégory; Zapardiel-Gonzalo, Jose; White, Brandie et al. (2016) Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma. J Immunol 197:655-64

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