The purpose of Core A is to provide administrative and project management support for the entire program and to ensure all projects and cores adhere to scientific, fiscal, and NIH reporting objectives. These functions will be crucial for the successful execution of the proposed work, given the relatively large number of cores and scientific projects participating, the extensive sharing of data and reagents envisioned amongst the different projects, and the aggressive timelines put forth from the team as whole. Although each project alone will provide important information to the field at large, extensive synergy and coordination is required to fully realize the Program's potential. Core A will specifically employ the effort of a Project Manager and a variety of Project Management functions to specifically coordinate and support each project. These will include formal program planning, monitoring, status reporting and project scheduling. In addition, a key function of Core A will be to facilitate and assist communication amongst Pis and Projects in the form of information and data exchange, preparation and submission of manuscripts, coordination/scheduling of meetings and teleconferences. In parallel, a series of activities will ensure productive communication with NIH and appointed officers including preparation and submission of NIH reports and faciltating attendance of appropriate team leaders to NIH meetings and/or conference calls. Finally the Administrative Core will oversee compliance of the overall Program and individual projects and cores with respect to fiscal and reporting obligations.

Public Health Relevance

This core will be in charge of administrative aspects of the Program. It will organize and facilitate communication amongst the various Projects participating in the Program, be responsible for monitoring progress, coordinating activities and communicating with NIAID Officers. Core A will ensure that appropriate reports are filed and that the different Projects, and the Program as a whole, adhere to the allotted budgets.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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La Jolla Institute
La Jolla
United States
Zip Code
Oseroff, Carla; Christensen, Lars H; Westernberg, Luise et al. (2017) Immunoproteomic analysis of house dust mite antigens reveals distinct classes of dominant T cell antigens according to function and serological reactivity. Clin Exp Allergy 47:577-592
Sette, Alessandro; Schulten, Véronique (2017) It's a lot of work to be nonallergic. J Allergy Clin Immunol 139:769-770
Schulten, Véronique; Tripple, Victoria; Seumois, Grégory et al. (2017) Allergen-specific immunotherapy modulates the balance of circulating Tfh and Tfr cells. J Allergy Clin Immunol :
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Schmiedel, Benjamin Joachim; Seumois, Grégory; Samaniego-Castruita, Daniela et al. (2016) 17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells. Nat Commun 7:13426
Oseroff, Carla; Pham, John; Frazier, April et al. (2016) Immunodominance in allergic T-cell reactivity to Japanese cedar in different geographic cohorts. Ann Allergy Asthma Immunol 117:680-689.e1
Engel, Isaac; Seumois, Grégory; Chavez, Lukas et al. (2016) Innate-like functions of natural killer T cell subsets result from highly divergent gene programs. Nat Immunol 17:728-39
Pham, J; Oseroff, C; Hinz, D et al. (2016) Sequence conservation predicts T cell reactivity against ragweed allergens. Clin Exp Allergy 46:1194-205
Schulten, V; Tripple, V; Aasbjerg, K et al. (2016) Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy. Clin Exp Allergy 46:439-48
Seumois, Grégory; Zapardiel-Gonzalo, Jose; White, Brandie et al. (2016) Transcriptional Profiling of Th2 Cells Identifies Pathogenic Features Associated with Asthma. J Immunol 197:655-64

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