The Chronic Rhinosinusitis Integrative Research Program (CRISP) is focused on significantly moving forward the field of research on chronic rhinosinusitis (CRS) by proposing novel and exciting approaches integrating Epidemiology, Genetics and Immunology. The PI of Core A is Dr. Robert Schleimer, who is assisted by Ms Valarie Thomas and Ms Jennifer Felten, two senior administrators at the Northwestern University Feinberg School of Medicine. The primary purposes ofthe Administrative Core A are to: provide central administrative services for CRISP and the participating centers;to facilitate communications among the investigators of CRISP and convene Advisory Boards;to assure the dissemination of discoveries made by CRISP investigators;to promote the training of young investigators to pursue CRS research;and to promote the synergies that result from interdisciplinary collaborations. Since the Projects of CRISP are situated in three distinct sites and represent three distinct disciplines, we will have quarterly meetings of all CRISP participating investigators. Two annual meetings will convene in Chicago and two will utilize videoconference technology. We will have an Internal Advisory Board meeting every year and an External Advisory Board every year. We will structure internet-based data sharing facilities, including a HIPAA compliant REDCap system and a hosted password protected website. We will mount a CRISP website for the use ofthe public and investigators of CRISP. Core A will be responsible for all fiduciary and reporting duties associated with the grant. We will innovate a grant program for MD or PhD students or fellows to promote interest in pursuing careers in CRS. CRISP will also play an important role in mentoring junior faculty with the same interests. Core A will monitor transfers of clinical samples and associated data among the participating centers managed by Core B, the Clinical, Laboratory and Data Management Core. Core A will assure the fulfillment of duties by Core B and the CRISP Projects. The PI of Core A will insure that the three Projects of CRISP, and the investigators in distinct disciplines that make them up, strive to capture the utmost ofthe synergies that can be realized from this highly integrative and collaborative project.

Public Health Relevance

CRISP consists of three Projects and two Cores, and is geared toward a deeper understanding ofthe epidemiology, genetics and pathogenesis of chronic rhinosinusitis, a disease that affects tens of millions of Americans. Core A will supervise the entire research program and assume administrative responsibility for the budget, publication process, advisory board meetings and educational program. Most importantly. Core A will promote synergy and integrate the research efforts among investigators in CRISP

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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Northwestern University at Chicago
United States
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Rosati, Mariel G; Peters, Anju T (2016) Relationships among allergic rhinitis, asthma, and chronic rhinosinusitis. Am J Rhinol Allergy 30:44-7
Tan, Bruce K; Klingler, Aiko I; Poposki, Julie A et al. (2016) Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois. J Allergy Clin Immunol :
Stevens, Whitney W; Schleimer, Robert P (2016) Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis. Immunol Allergy Clin North Am 36:669-680
Stevens, Whitney W; Schleimer, Robert P; Kern, Robert C (2016) Chronic Rhinosinusitis with Nasal Polyps. J Allergy Clin Immunol Pract 4:565-72
Ajmani, Gaurav S; Suh, Helen H; Pinto, Jayant M (2016) Effects of Ambient Air Pollution Exposure on Olfaction: A Review. Environ Health Perspect 124:1683-1693
Poposki, Julie A; Keswani, Anjeni; Kim, Julie K et al. (2016) Tissue proteases convert CCL23 into potent monocyte chemoattractants in patients with chronic rhinosinusitis. J Allergy Clin Immunol 137:1274-1277.e9
Jairaman, Amit; Maguire, Chelsea H; Schleimer, Robert P et al. (2016) Allergens stimulate store-operated calcium entry and cytokine production in airway epithelial cells. Sci Rep 6:32311
Schleimer, Robert P; Schnaar, Ronald L; Bochner, Bruce S (2016) Regulation of airway inflammation by Siglec-8 and Siglec-9 sialoglycan ligand expression. Curr Opin Allergy Clin Immunol 16:24-30
Divekar, Rohit; Hagan, John; Rank, Matthew et al. (2016) Diagnostic Utility of Urinary LTE4 in Asthma, Allergic Rhinitis, Chronic Rhinosinusitis, Nasal Polyps, and Aspirin Sensitivity. J Allergy Clin Immunol Pract 4:665-70
Bose, Sumit; Grammer, Leslie C; Peters, Anju T (2016) Infectious Chronic Rhinosinusitis. J Allergy Clin Immunol Pract 4:584-9

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