The administrative core will provide a management plan to coordinate the whole FLUOMICS consortium by 1) the establishment of an organizational structure centered around an Executive Committee responsible for monitoring overall program progress, implementing a Pilot Research Program, and making decisions on staffing plans, allocation of resources, scientific core usage and other policies;2) the coordination of conference calls and of annual meetings between the Pis, selected key personnel, the Steering Committee and NIAID;3) assisting the members of this consortium in reagents and data sharing, manuscript preparations, public release of data and submission of annual progress reports to the NIH;and 4) providing training opportunities in Systems Biology for the infection disease scientist. The Core Director has expertise in the coordination of program projects and big consortiums, as he is the Director of one of the NIAID Centers of Excellence of Influenza Research and Surveillance. This FLUOMICS proposal complements and does not overlap with the Center of Excellence, as the influenza center does not include the use of a systems biology approach in its research agenda. The Core Co-Director is in charge ofthe training program to be implemented in years 2 to 5 and he has past experience in organizing training for students in systems biology approaches.
We are planning to create an innovative discovery platform integrating global scale OMICS and systems biology approaches to identify novel host genes and immune networks that impact susceptibility to influenza virus infection. This will be done through an intercollaborative multidisciplinary approach involving 3 scientific projects, 3 -OMICS cores, a Modeling Core, a Virus Core, a Data Management and Resources Dissemination Core and 8 different institutions. The administrative will take care of coordinating such a complex organization to assure maximal research progress, and organize a training symposia in systems biology.
|Pohl, Marie O; von Recum-Knepper, Jessica; Rodriguez-Frandsen, Ariel et al. (2017) Identification of Polo-like kinases as potential novel drug targets for influenza A virus. Sci Rep 7:8629|
|Hartmann, Boris M; Albrecht, Randy A; Zaslavsky, Elena et al. (2017) Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death. Nat Commun 8:1931|
|Lobingier, Braden T; Hüttenhain, Ruth; Eichel, Kelsie et al. (2017) An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell 169:350-360.e12|
|Rialdi, Alexander; Hultquist, Judd; Jimenez-Morales, David et al. (2017) The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity. Cell 169:679-692.e14|
|Soonthornvacharin, Stephen; Rodriguez-Frandsen, Ariel; Zhou, Yingyao et al. (2017) Systems-based analysis of RIG-I-dependent signalling identifies KHSRP as an inhibitor of RIG-I receptor activation. Nat Microbiol 2:17022|
|García-Sastre, Adolfo (2017) Ten Strategies of Interferon Evasion by Viruses. Cell Host Microbe 22:176-184|
|Martín-Vicente, María; Medrano, Luz M; Resino, Salvador et al. (2017) TRIM25 in the Regulation of the Antiviral Innate Immunity. Front Immunol 8:1187|
|Patzina, Corinna; Botting, Catherine H; García-Sastre, Adolfo et al. (2017) Human interactome of the influenza B virus NS1 protein. J Gen Virol 98:2267-2273|
|Park, Ryan J; Wang, Tim; Koundakjian, Dylan et al. (2017) A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat Genet 49:193-203|
|Schotsaert, Michael; García-Sastre, Adolfo (2017) Inactivated influenza virus vaccines: the future of TIV and QIV. Curr Opin Virol 23:102-106|
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