The goal ofthe Metabolomics Core (Core D) is to provide a central resource that will facilitate high throughput characterization ofthe metabolome in influenza virus infected cells and fissues. We will validate relevant metabolites and localize metabolites within infected fissues samples. The core will also design strategies to uncover host metabolic pathways that are impacted by, and that influence influenza virus infecfion and disease pathogenesis.
An better understanding of influenza infecfion and pathogenesis requires state-of-the-art tools for measuring the metabolism of infected cells. This Core will perform analysis of small metabolites associated with virus infecfion. These studies will help to define the fundamental ways that influenza causes disease
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