Building a predictive model for influenza pathogenesis will require reiterative cycles of data generation and computational analysis. Given the role of large-scale datasets in this effort, effective data management and resource dissemination is critical for not only the success of the program, but for the broader scientific community to fully realize and exploit resources generated by this Center. Towards that end, the Data Management and Resource Dissemination Core will act as a central repository for all data and resources generated by the Center, and ensure that these materials are readily accessible by not only other scientists in the program, but also the broader scientific community. The Core will adapt practices, protocols, approaches, and software that have been previously and successfully utilized to integrate and disseminate large-scale datasets within the context of a large program project. Internally, we will focus on project tracking, data consolidation and integration, quality control, and managing a centralized database that is accessible and user-friendly. In addition, the core will work to integrate publically available data, and make these integrated large-scale datasets, and associated resources, available to the scientific community to enable the exploration of novel hypothesis based on the information generated by the program.

Public Health Relevance

This Fluomics project is centered on the acquisition, processing, and analysis of systems-level datasets ('BIG DATA') to drive predictive models of pathogenesis. Consolidation, integration, and quality control of these large datasets, therefore, is critical to a successful outcome of this project. The Data Management and Dissemination core will leverage experience, software, and standard operating procedures from previous projects involving similar management of datasets to ensure that results generated in the program are accessible to all members of the project, as well as the broader scientific community.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
Project #
Application #
Study Section
Special Emphasis Panel (ZAI1-EC-M)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Icahn School of Medicine at Mount Sinai
New York
United States
Zip Code
Morris, John H; Knudsen, Giselle M; Verschueren, Erik et al. (2014) Affinity purification-mass spectrometry and network analysis to understand protein-protein interactions. Nat Protoc 9:2539-54
Rajsbaum, Ricardo; Versteeg, Gijs A; Schmid, Sonja et al. (2014) Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKK? kinase-mediated antiviral response. Immunity 40:880-95
Rajsbaum, Ricardo; Garcia-Sastre, Adolfo; Versteeg, Gijs A (2014) TRIMmunity: the roles of the TRIM E3-ubiquitin ligase family in innate antiviral immunity. J Mol Biol 426:1265-84
Schotsaert, Michael; GarcĂ­a-Sastre, Adolfo (2014) Influenza vaccines: a moving interdisciplinary field. Viruses 6:3809-26