The Administrative Core for the project entitled """"""""Modeling Host Responses to Understand Severe Human Virus Infections"""""""" will provide support to the Research projects (RPI: Influenza and Ebola virus research;RP2: West Nile virus research project) and the other project cores (Core A: Proteomics, Metabolomics and Lipidomics Core;Core B: Computational Modeling Core;Core C: Data Dissemination and Resource Sharing Core) and coordinate project activities. The overall objective of the project is to characterize host cell responses that determine the outcome of potentially lethal viral infections. As Principal Investigator and Leader of the Administrative Core, Dr. Yoshihiro Kawaoka will be responsible for the overall project and for meeting the objectives outlined. The Administrative Core will (1) assemble the staff needed to meet the objectives outlined in the project proposal, ensuring the expertise and commitment is commensurate with project goals;(2) identify milestones and establish timelines which will be reviewed frequently to keep the project on target;(3) oversee budget resources to. optimize outputs and ensure spending is appropriate;(4) foster good communications among members of the projects and cores via regular webcasts, in-person meetings and frequent email contact, and provide regular interaction with the NIAID Project Scientist and the Steering Committee;(5) support the data management and resource sharing objectives, curate the Laboratory Information Management System (LIMS), ensure data sharing within the project is optimized, and that data and resources are shared promptly via a public web portal for data and public repositories for data, analyses, software, models and biological resources;(6) develop a Training Program to help other infectious disease researchers learn about OMICs approaches and (7) establish a Pilot Research Program to fund short-term innovative projects relevant to the project.
Comprehensive and innovative approaches to determining host response to infection by highly pathogenic viruses will lead to a better understanding of these serious diseases and support the development of improved therapeutics.
|Nakayasu, Ernesto S; Nicora, Carrie D; Sims, Amy C et al. (2016) MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses. mSystems 1:|
|Gorman, Matthew J; Poddar, Subhajit; Farzan, Michael et al. (2016) The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. J Virol 90:8212-25|
|Zhang, Rong; Miner, Jonathan J; Gorman, Matthew J et al. (2016) A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature 535:164-8|
|Bowen, James R; Ferris, Martin T; Suthar, Mehul S (2016) Systems biology: A tool for charting the antiviral landscape. Virus Res 218:2-9|
|Wang, Mingxun; Carver, Jeremy J; Phelan, Vanessa V et al. (2016) Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol 34:828-37|
|Kyle, Jennifer E; Zhang, Xing; Weitz, Karl K et al. (2016) Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry. Analyst 141:1649-59|
|Burnum-Johnson, Kristin E; Nie, Song; Casey, Cameron P et al. (2016) Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry. Mol Cell Proteomics 15:3694-3705|
|Hyde, Jennifer L; Diamond, Michael S (2015) Innate immune restriction and antagonism of viral RNA lacking 2×³-O methylation. Virology 479-480:66-74|
|Totura, Allison L; Whitmore, Alan; Agnihothram, Sudhakar et al. (2015) Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. MBio 6:e00638-15|
|Lazear, Helen M; Diamond, Michael S (2015) New insights into innate immune restriction of West Nile virus infection. Curr Opin Virol 11:1-6|
Showing the most recent 10 out of 17 publications