The goal of Core C - Data Management and Resources Dissemination (DMRD) is to provide a centralized repository for the various systems biology datasets, programmatic tools and results generated by the """"""""Modeling Host Responses to Understand Severe Human Virus Infections"""""""" project, and to make this repository easily accessible to the members of the research team as well as the wider scientific community. The DMRD will be responsible for providing IT hardware and software support to establish and maintain a centralized database integrated with a Laboratory Information Management System, that will be used to track complex experimental flows, exchange data and information between the experimentalists and computational scientists, and facilitate collaboration between the various team members of this multidisplinary and multi-Pl research effort. To enable the wider scientific community to benefit from the research of this project, this core will coordinate with other components of the project to rapidly deposit data to public repositories and setup a dedicated web-portal that will provide information about the major milestones of the project to enable the wider systems biology and virology community to have unified access to the resources generated by this project.
Systematic data integration of the rich OMICs datasets collected by the various components of this project to gain a systems level understanding human host response to pathogenic viruses, requires a dependable and flexible data management system. In addition, rapid and efficient sharing of information between team members and the general community are essential for the broader impact of this project.
|Nakayasu, Ernesto S; Nicora, Carrie D; Sims, Amy C et al. (2016) MPLEx: a Robust and Universal Protocol for Single-Sample Integrative Proteomic, Metabolomic, and Lipidomic Analyses. mSystems 1:|
|Gorman, Matthew J; Poddar, Subhajit; Farzan, Michael et al. (2016) The Interferon-Stimulated Gene Ifitm3 Restricts West Nile Virus Infection and Pathogenesis. J Virol 90:8212-25|
|Zhang, Rong; Miner, Jonathan J; Gorman, Matthew J et al. (2016) A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature 535:164-8|
|Bowen, James R; Ferris, Martin T; Suthar, Mehul S (2016) Systems biology: A tool for charting the antiviral landscape. Virus Res 218:2-9|
|Wang, Mingxun; Carver, Jeremy J; Phelan, Vanessa V et al. (2016) Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking. Nat Biotechnol 34:828-37|
|Kyle, Jennifer E; Zhang, Xing; Weitz, Karl K et al. (2016) Uncovering biologically significant lipid isomers with liquid chromatography, ion mobility spectrometry and mass spectrometry. Analyst 141:1649-59|
|Burnum-Johnson, Kristin E; Nie, Song; Casey, Cameron P et al. (2016) Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry. Mol Cell Proteomics 15:3694-3705|
|Hyde, Jennifer L; Diamond, Michael S (2015) Innate immune restriction and antagonism of viral RNA lacking 2×³-O methylation. Virology 479-480:66-74|
|Totura, Allison L; Whitmore, Alan; Agnihothram, Sudhakar et al. (2015) Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. MBio 6:e00638-15|
|Lazear, Helen M; Diamond, Michael S (2015) New insights into innate immune restriction of West Nile virus infection. Curr Opin Virol 11:1-6|
Showing the most recent 10 out of 17 publications