The goal of Core C - Data Management and Resources Dissemination (DMRD) is to provide a centralized repository for the various systems biology datasets, programmatic tools and results generated by the """"""""Modeling Host Responses to Understand Severe Human Virus Infections"""""""" project, and to make this repository easily accessible to the members of the research team as well as the wider scientific community. The DMRD will be responsible for providing IT hardware and software support to establish and maintain a centralized database integrated with a Laboratory Information Management System, that will be used to track complex experimental flows, exchange data and information between the experimentalists and computational scientists, and facilitate collaboration between the various team members of this multidisplinary and multi-Pl research effort. To enable the wider scientific community to benefit from the research of this project, this core will coordinate with other components of the project to rapidly deposit data to public repositories and setup a dedicated web-portal that will provide information about the major milestones of the project to enable the wider systems biology and virology community to have unified access to the resources generated by this project.

Public Health Relevance

Systematic data integration of the rich OMICs datasets collected by the various components of this project to gain a systems level understanding human host response to pathogenic viruses, requires a dependable and flexible data management system. In addition, rapid and efficient sharing of information between team members and the general community are essential for the broader impact of this project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI106772-02
Application #
8667406
Study Section
Special Emphasis Panel (ZAI1-EC-M)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
2
Fiscal Year
2014
Total Cost
$174,691
Indirect Cost
$58,617
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Zheng, Xueyun; Renslow, Ryan S; Makola, Mpho M et al. (2017) Structural Elucidation of cis/trans Dicaffeoylquinic Acid Photoisomerization Using Ion Mobility Spectrometry-Mass Spectrometry. J Phys Chem Lett 8:1381-1388
Zheng, Xueyun; Deng, Liulin; Baker, Erin S et al. (2017) Distinguishing d- and l-aspartic and isoaspartic acids in amyloid ? peptides with ultrahigh resolution ion mobility spectrometry. Chem Commun (Camb) 53:7913-7916
Burnum-Johnson, Kristin E; Kyle, Jennifer E; Eisfeld, Amie J et al. (2017) MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling. Analyst 142:442-448
Menachery, Vineet D; Mitchell, Hugh D; Cockrell, Adam S et al. (2017) MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis. MBio 8:
Schäfer, Alexandra; Baric, Ralph S (2017) Epigenetic Landscape during Coronavirus Infection. Pathogens 6:
Zheng, Xueyun; Wojcik, Roza; Zhang, Xing et al. (2017) Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses. Annu Rev Anal Chem (Palo Alto Calif) 10:71-92
Kyle, Jennifer E; Casey, Cameron P; Stratton, Kelly G et al. (2017) Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies. Rapid Commun Mass Spectrom 31:447-456
Menachery, Vineet D; Gralinski, Lisa E; Mitchell, Hugh D et al. (2017) Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis. mSphere 2:
Kyle, Jennifer E; Crowell, Kevin L; Casey, Cameron P et al. (2017) LIQUID: an-open source software for identifying lipids in LC-MS/MS-based lipidomics data. Bioinformatics 33:1744-1746
Eisfeld, Amie J; Halfmann, Peter J; Wendler, Jason P et al. (2017) Multi-platform 'Omics Analysis of Human Ebola Virus Disease Pathogenesis. Cell Host Microbe 22:817-829.e8

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