The Data Management and Resource Dissemination Core (DMRDC) will: a) provide the infrastructure to aid hypothesis generation, b) integrate public and private databases, c) store results of bioinformatic analyses, d) store and organize experimental functional and biochemical data, e) facilitate material and project management, f) enable seamless interaction between the administrative core, technology core and the research projects, and g) provide a public data access gateway. This Core is committed to providing the scientific community a query interface to all information derived from bioinformatics analyses, experimental functional and biochemical experiments on pathogens and purified gene products, and biological and biochemical reagents. Our NIAID project will generate a large amount of data during the 5-year award term. The efficient management of these data is crucial for the success of the proposed work. Publicly available resources will be utilized in order to reduce redundancies in efforts. In return, the resources generated by this program will be made available in a form that enables simple integration into other resources. Data release into the public domain will be governed by the Administrative core and will adhere to NIAID/NIH policies.
Large collaborative projects have the potential to outperform a group of smaller research projects with similar scope and size. This synergy can be realized only when experimental data, resources, and information are shared efficiently across the performance sites. This proposal aims to generate the informatics framework to bring this synergy to fruition.
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|Herrou, Julien; Willett, Jonathan W; Czy?, Daniel M et al. (2017) Conserved ABC Transport System Regulated by the General Stress Response Pathways of Alpha- and Gammaproteobacteria. J Bacteriol 199:|
|Baric, Ralph S; Crosson, Sean; Damania, Blossom et al. (2016) Next-Generation High-Throughput Functional Annotation of Microbial Genomes. MBio 7:|
|Herrou, Julien; Czy?, Daniel M; Willett, Jonathan W et al. (2016) WrpA Is an Atypical Flavodoxin Family Protein under Regulatory Control of the Brucella abortus General Stress Response System. J Bacteriol 198:1281-93|
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|Meyer, Peter A; Socias, Stephanie; Key, Jason et al. (2016) Data publication with the structural biology data grid supports live analysis. Nat Commun 7:10882|
|Willett, Jonathan W; Herrou, Julien; Briegel, Ariane et al. (2015) Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen. Proc Natl Acad Sci U S A 112:E3709-18|
|Kim, Hye-Sook; Willett, Jonathan W; Jain-Gupta, Neeta et al. (2014) The Brucella abortus virulence regulator, LovhK, is a sensor kinase in the general stress response signalling pathway. Mol Microbiol 94:913-25|
|Tam, Christina; Demke, Owen; Hermanas, Timothy et al. (2014) YfbA, a Yersinia pestis regulator required for colonization and biofilm formation in the gut of cat fleas. J Bacteriol 196:1165-73|
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