Data Management and Resource Dissemination Core: this core fullfills requirements of the RFA. First, the core provides for, organizes and performs sample tracking, data integration and management of data. This functionality will be provided by a central server and web interface. The core will develop, distribute and enforce SOPs for the project. Because we expect information to come from a variety of experimental technologies the core will be essential for the efficient and successful perfonnance of the program. Second, the core will integrate the data from the different biochemical assays and establish a database, which links them to specific orfs, miRNAs, and IncRNAs. Third, the will provide resources for computationally intensive processes, and if necessary develop job scheduling and interfaces to the UNC """"""""Kure"""""""" high perfonnance computing cluster. Forth, this core will provide statistical support and central QC/QA for all biochemical assays performed in this project. The core operates under good clinical laboratory practices (GLP). Lastly, the core will be responsible for timely dissemination of data and reagents to public repositories and the research community at large. We are fortunate in that UNC's department of Microbiology and Immunonology already established a dedictated facility to support genomic, screening and translational studies in Virology. This facility, (www.med.unc.edu/vironomlcs) will provide the physical infrastrcuture and expertise, which will be augment by new servers dedicated to this project.
A common analysis of the data will provide a deeper understanding of the specific pathways that are affected by the uncharacterized orfs, miRNAs and novel IncRNAs. Communication of this information within the group and to the larger research community will help to foster the development of new antiviral therapies and improved vaccines.
|Hsia, Hung-Ching; Stopford, Charles M; Zhang, Zhigang et al. (2017) Signal transducer and activator of transcription 3 (Stat3) regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection. J Leukoc Biol 101:1053-1064|
|Widman, Douglas G; Young, Ellen; Yount, Boyd L et al. (2017) A Reverse Genetics Platform That Spans the Zika Virus Family Tree. MBio 8:|
|Gallichotte, Emily N; Dinnon 3rd, Kenneth H; Lim, Xin-Ni et al. (2017) CD-loop Extension in Zika Virus Envelope Protein Key for Stability and Pathogenesis. J Infect Dis 216:1196-1204|
|Menachery, Vineet D; Graham, Rachel L; Baric, Ralph S (2017) Jumping species-a mechanism for coronavirus persistence and survival. Curr Opin Virol 23:1-7|
|Schifano, Jason M; Corcoran, Kathleen; Kelkar, Hemant et al. (2017) Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus. J Virol 91:|
|Corcoran, Kathleen; Sherrod, Carly J; Perkowski, Ellen F et al. (2017) Genome Sequences of Diverse Human Cytomegalovirus Strains with Utility in Drug Screening and Vaccine Evaluation. Genome Announc 5:|
|Baric, Ralph S; Crosson, Sean; Damania, Blossom et al. (2016) Next-Generation High-Throughput Functional Annotation of Microbial Genomes. MBio 7:|
|Zhang, Zhigang; Chen, Wuguo; Sanders, Marcia K et al. (2016) The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Augments Viral Lytic Replication. J Virol 90:7657-66|
|Dittmer, Dirk P (2016) Zika vaccine: Clinical trial and error? Science 353:1375|
|McVoy, Michael A; Wang, Jian Ben; Dittmer, Dirk P et al. (2016) Repair of a Mutation Disrupting the Guinea Pig Cytomegalovirus Pentameric Complex Acquired during Fibroblast Passage Restores Pathogenesis in Immune-Suppressed Guinea Pigs and in the Context of Congenital Infection. J Virol 90:7715-27|
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