Data Management and Resource Dissemination Core: this core fullfills requirements of the RFA. First, the core provides for, organizes and performs sample tracking, data integration and management of data. This functionality will be provided by a central server and web interface. The core will develop, distribute and enforce SOPs for the project. Because we expect information to come from a variety of experimental technologies the core will be essential for the efficient and successful perfonnance of the program. Second, the core will integrate the data from the different biochemical assays and establish a database, which links them to specific orfs, miRNAs, and IncRNAs. Third, the will provide resources for computationally intensive processes, and if necessary develop job scheduling and interfaces to the UNC "Kure" high perfonnance computing cluster. Forth, this core will provide statistical support and central QC/QA for all biochemical assays performed in this project. The core operates under good clinical laboratory practices (GLP). Lastly, the core will be responsible for timely dissemination of data and reagents to public repositories and the research community at large. We are fortunate in that UNC's department of Microbiology and Immunonology already established a dedictated facility to support genomic, screening and translational studies in Virology. This facility, ( will provide the physical infrastrcuture and expertise, which will be augment by new servers dedicated to this project.

Public Health Relevance

A common analysis of the data will provide a deeper understanding of the specific pathways that are affected by the uncharacterized orfs, miRNAs and novel IncRNAs. Communication of this information within the group and to the larger research community will help to foster the development of new antiviral therapies and improved vaccines.

National Institute of Health (NIH)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1)
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University of North Carolina Chapel Hill
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Hosseinipour, Mina C; Sweet, Kristen M; Xiong, Jie et al. (2014) Viral profiling identifies multiple subtypes of Kaposi's sarcoma. MBio 5:e01633-14
Cockrell, Adam S; Peck, Kayla M; Yount, Boyd L et al. (2014) Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection. J Virol 88:5195-9
Zhang, Lu; Mo, Jinyao; Swanson, Karen V et al. (2014) NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING. Immunity 40:329-41
Menachery, Vineet D; Yount Jr, Boyd L; Josset, Laurence et al. (2014) Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity. J Virol 88:4251-64
West, John A; Wicks, Megan; Gregory, Sean M et al. (2014) An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle. J Virol 88:5778-87
Agnihothram, Sudhakar; Gopal, Robin; Yount Jr, Boyd L et al. (2014) Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses. J Infect Dis 209:995-1006
Deng, Xufang; Agnihothram, Sudhakar; Mielech, Anna M et al. (2014) A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronaviruses. J Virol 88:11825-33
Yang, Dongmei; Chen, Wuguo; Xiong, Jie et al. (2014) Interleukin 1 receptor-associated kinase 1 (IRAK1) mutation is a common, essential driver for Kaposi sarcoma herpesvirus lymphoma. Proc Natl Acad Sci U S A 111:E4762-8
Agnihothram, Sudhakar; Yount Jr, Boyd L; Donaldson, Eric F et al. (2014) A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant. MBio 5:e00047-14
Giffin, Louise; Yan, Feng; Ben Major, M et al. (2014) Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1. J Virol 88:9429-41

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