Core B ? Abstract In this adjuvant-enhanced and electroporation-delivered DNA prime-protein boost HIV vaccine development program, the availability of high-quality and well-developed recombinant Env protein vaccine components are critical to the success of entire program. Core B is designed to provide non-GMP recombinant Env proteins for proposed pre-clinical animal studies, including non-human primate studies, and to advise on scientific and technical issues related to the production of GMP-grade recombinant Env proteins for planned phase I clinical studies. The PI of Core B, Dr. Shan Lu, has developed a polyvalent gp120 protein formulation from his previous NIH-funded programs. That formulation includes four recombinant gp120 proteins (covering HIV-1 subtypes A, B, C, and AE) produced using the CHO system under GMP conditions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
5U19AI109646-03
Application #
9261463
Study Section
Special Emphasis Panel (ZAI1-EC-A)
Project Start
Project End
Budget Start
2017-03-01
Budget End
2018-02-28
Support Year
3
Fiscal Year
2017
Total Cost
$401,998
Indirect Cost
Name
Wistar Institute
Department
Internal Medicine/Medicine
Type
Research Institutes
DUNS #
075524595
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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Kutzler, M A; Wise, M C; Hutnick, N A et al. (2016) Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge. Mucosal Immunol 9:13-23

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