Core of the Antiviral Drug Discovery and Development Center (ADSC) will provide a key role in leadership, communication, coordination and oversight ofthe projects and cores, and stimulate collaboration and synergy between the projects. Operationally, it is in charge of fiscal and contractual management of the center and will plan and implement activities, such as meetings of the Executive Committee (EC), External Scientific Advisory Board (EAB), and an annual meeting of all projects and cores. In addition, it will manage the inter-institutional cooperative agreements. The core is also responsible for managing the solicitation and review of Supplemental Research Projects applications, such as those for additional product development and support for IND-enabling studies. Finally, the core will facilitate dissemination of progress and discoveries to the public.

Public Health Relevance

The Administrative Core will provide information and assistance to Antiviral Drug Discovery and Development Center project investigators who are developing potential therapies for emerging infections such as West Nile virus and influenza. The Core will also assist with preparing reports and publications that will allow public access to data and results that are collected as part of the scientific research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109680-01
Application #
8650371
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$165,117
Indirect Cost
$6,269
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
McCarthy, Mary K; Morrison, Thomas E (2017) Persistent RNA virus infections: do PAMPS drive chronic disease? Curr Opin Virol 23:8-15
Pryke, Kara M; Abraham, Jinu; Sali, Tina M et al. (2017) A Novel Agonist of the TRIF Pathway Induces a Cellular State Refractory to Replication of Zika, Chikungunya, and Dengue Viruses. MBio 8:
Sheahan, Timothy P; Sims, Amy C; Graham, Rachel L et al. (2017) Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med 9:
Haese, Nicole N; Broeckel, Rebecca M; Hawman, David W et al. (2016) Animal Models of Chikungunya Virus Infection and Disease. J Infect Dis 214:S482-S487
McCarthy, Mary K; Morrison, Thomas E (2016) Chronic chikungunya virus musculoskeletal disease: what are the underlying mechanisms? Future Microbiol 11:331-4
Everts, Maaike; Suto, Mark J; Painter, George R et al. (2016) Consortia's critical role in developing medical countermeasures for re-emerging viral infections: a USA perspective. Future Virol 11:187-195
Rasmussen, Lynn; White, E Lucile; Bostwick, James R (2016) Acoustic Droplet Ejection Applications for High-Throughput Screening of Infectious Agents. J Lab Autom 21:188-97
Morrison, Clayton R; Plante, Kenneth S; Heise, Mark T (2016) Chikungunya Virus: Current Perspectives on a Reemerging Virus. Microbiol Spectr 4:
Mounce, Bryan C; Cesaro, Teresa; Moratorio, Gonzalo et al. (2016) Inhibition of Polyamine Biosynthesis Is a Broad-Spectrum Strategy against RNA Viruses. J Virol 90:9683-9692
Mainou, Bernardo A; Ashbrook, Alison W; Smith, Everett Clinton et al. (2015) Serotonin Receptor Agonist 5-Nonyloxytryptamine Alters the Kinetics of Reovirus Cell Entry. J Virol 89:8701-12

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