The Discovery and Translational Services will provide commonly needed services that require specialized equipment and capabilities that are not generally available in a typical microbiological research laboratory, additional expertise to investigators in fields outside their areas of specialization, access to research technologies not otherwise available and to translational and product development capabilities These services will include both services provided by core staff and services provided on a fee-for-service basis. The core will make use of a management structure that encourages productive and creative collaboration and allows integration and coordination between research project investigators and core scientific staff. The specific services provided or made available include: ? biomolecule production ? small molecule screening ? medicinal chemistry ? discovery formulation ? assessment of compound toxicity

Public Health Relevance

Individual investigators do not possess all ofthe expertise, equipment, and capabilities necessary to complete the discovery and translational objectives of the Center. This core will either provide needed research services directly or through fee for service relationships with other research service providers. The core will also be a source of translational expertise available to all Center investigators.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109740-01
Application #
8655313
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$856,364
Indirect Cost
$208,260
Name
Harvard University
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Carocci, Margot; Hinshaw, Stephen M; Rodgers, Mary A et al. (2015) The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication. Antimicrob Agents Chemother 59:85-95
Chao, Luke H; Klein, Daryl E; Schmidt, Aaron G et al. (2014) Sequential conformational rearrangements in flavivirus membrane fusion. Elife 3:e04389
Jae, Lucas T; Raaben, Matthijs; Herbert, Andrew S et al. (2014) Virus entry. Lassa virus entry requires a trigger-induced receptor switch. Science 344:1506-10