The primary objective of the Administrative Core is to provide the support structures for the management, coordination, and evaluation ofthe Center's activities. The Administrative Core will: ? Maintain a Scientific Advisory Committee whose members will review and recommend changes to the Center's strategic direction, assist Center leadership in making prioritization decisions, maintain institutional support arid commitment, and ensure that the Center's programs are continually evaluated for their progress and potential to meet the strategic objectives of the CETR program. ? Work collaboratively with Principal Investigators to support their research efforts through the use of the Center's core laboratory, to identify collaborators whose joint efforts could synergistically benefit the collaborators' research programs, and to identify additional resources, including those provided by NIAID and other government agencies, that could contribute to a successful research and product development effort. ? Assist Principal Investigators to create a path from research towards product development. The core may engage consultants with specific expertise in product development to advise investigators on creating a developmental plan and identifying additional resources and expertise such as contract manufacturing and regulatory affairs. ? Ensure financial accountability for the Center's resources by the use of financial management systems appropriate to a center with multiple investigator-initiated research programs, core facilities, contract research, and a supplemental projects initiative. ? Monitor and ensure regulatory compliance with regard to general laboratory safety, biosafety, select agent research, use and care of laboratory animals, and research involving human subjects. ? Monitor and evaluate the Center's research projects, core facilities, administrative systems, and funding of supplemental projects.
A well-coordinated and efficiently run and creative multi-project center depends on an effective Administrative operation to ensure that all components ofthe center are working together, exchanging ideas, and responding strategically to both research successes and roadblocks.
|Coulter, Michael E; Dorobantu, Cristina M; Lodewijk, Gerrald A et al. (2018) The ESCRT-III Protein CHMP1A Mediates Secretion of Sonic Hedgehog on a Distinctive Subtype of Extracellular Vesicles. Cell Rep 24:973-986.e8|
|Lian, Wenlong; Jang, Jaebong; Potisopon, Supanee et al. (2018) Discovery of Immunologically Inspired Small Molecules That Target the Viral Envelope Protein. ACS Infect Dis 4:1395-1406|
|de Wispelaere, Melissanne; Lian, Wenlong; Potisopon, Supanee et al. (2018) Inhibition of Flaviviruses by Targeting a Conserved Pocket on the Viral Envelope Protein. Cell Chem Biol 25:1006-1016.e8|
|Chao, Luke H; Jang, Jaebong; Johnson, Adam et al. (2018) How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion. Elife 7:|
|Pitts, Jared D; Li, Pi-Chun; de Wispelaere, Melissanne et al. (2017) Antiviral activity of N-(4-hydroxyphenyl) retinamide (4-HPR) against Zika virus. Antiviral Res 147:124-130|
|Salgado, Eric N; Upadhyayula, Srigokul; Harrison, Stephen C (2017) Single-particle detection of transcription following rotavirus entry. J Virol :|
|Raaben, Matthijs; Jae, Lucas T; Herbert, Andrew S et al. (2017) NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry. Cell Host Microbe 22:688-696.e5|
|Wang, May K; Lim, Sun-Young; Lee, Soo Mi et al. (2017) Biochemical Basis for Increased Activity of Ebola Glycoprotein in the 2013-16 Epidemic. Cell Host Microbe 21:367-375|
|Filippakis, Harilaos; Alesi, Nicola; Ogorek, Barbara et al. (2017) Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R. Oncotarget 8:38099-38112|
|Chou, Yi-Ying; Cuevas, Christian; Carocci, Margot et al. (2016) Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor. J Virol 90:4494-4510|
Showing the most recent 10 out of 25 publications