Accurate diagnosis is essential for proper medical treatment. Often this is confounded by the lack of or limitation of informative diagnostic assays and tools. Infectious agents rarely found in a given community or country commonly are not screened for as multiple single diagnostic assays are cost-prohibitive and tests for the most likely agent is deemed warranted. Yet it is increasingly clear that as infectious agents appear in new geographic regions and contexts, the medical and public heath communities must improve and modernize the methodologies they utilize. The Center for Research in Diagnostics and Discovery aims to develop, validate and implement multiplex platforms and predictive strategies that will advance detection of novel pathogens, identify host factors that influence susceptibility of disease and predict effectiveness of drugs and vaccines. We will bring together researchers in the fields of molecular biology, systems biology, genetics, and bioengineering. We will also bring together members of the public health communities and conservation biologists. Together, the investigators in the Center for Research in Diagnostics and Discovery will advance knowledge and platforms for the detection of agents that are either previously unidentified, known causes of epidemics, or select agents by developing and utilizing systems that could be rapidly redirected for pathogens of any type.

Public Health Relevance

Diagnostic assays are the primary point for medical treatment. The assays used today by the medical community do not provide the efficiency and multiplexing that are key to rapid diagnosis and accurate treatment. The Center for Research in Diagnostics and Discovery will apply and develop modern state-of-the-art technologies for the creation of new tools that can be informative to the medical community.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109761-01
Application #
8642446
Study Section
Special Emphasis Panel (ZAI1-LR-M (J1))
Program Officer
Schaefer, Michael R
Project Start
2014-03-07
Project End
2019-02-28
Budget Start
2014-03-07
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$6,269,460
Indirect Cost
$1,203,597
Name
Columbia University
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Lindow, Janet C; Wunder Jr, Elsio A; Popper, Stephen J et al. (2016) Cathelicidin Insufficiency in Patients with Fatal Leptospirosis. PLoS Pathog 12:e1005943
Bouilly, Delphine; Hon, Jason; Daly, Nathan S et al. (2016) Single-Molecule Reaction Chemistry in Patterned Nanowells. Nano Lett 16:4679-85
Bacharach, Eran; Mishra, Nischay; Briese, Thomas et al. (2016) Characterization of a Novel Orthomyxo-like Virus Causing Mass Die-Offs of Tilapia. MBio 7:e00431-16
Beall, Anne; Yount, Boyd; Lin, Chun-Ming et al. (2016) Characterization of a Pathogenic Full-Length cDNA Clone and Transmission Model for Porcine Epidemic Diarrhea Virus Strain PC22A. MBio 7:e01451-15
Forero, Adriana; Tisoncik-Go, Jennifer; Watanabe, Tokiko et al. (2016) The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice. J Virol 90:2240-53
Tisoncik-Go, Jennifer; Gasper, David J; Kyle, Jennifer E et al. (2016) Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism. Cell Host Microbe 19:254-66
Warren, Steven B; Vernick, Sefi; Romano, Ethan et al. (2016) Complementary Metal-Oxide-Semiconductor Integrated Carbon Nanotube Arrays: Toward Wide-Bandwidth Single-Molecule Sensing Systems. Nano Lett 16:2674-9
Strouts, Fiona R; Popper, Stephen J; Partidos, Charalambos D et al. (2016) Early Transcriptional Signatures of the Immune Response to a Live Attenuated Tetravalent Dengue Vaccine Candidate in Non-human Primates. PLoS Negl Trop Dis 10:e0004731
Menachery, Vineet D; Yount Jr, Boyd L; Sims, Amy C et al. (2016) SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci U S A 113:3048-53
Tokarz, Rafal; Sameroff, Stephen; Hesse, Richard A et al. (2015) Discovery of a novel nidovirus in cattle with respiratory disease. J Gen Virol 96:2188-93

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