This Administrative Core (Core A) will provide the necessary scientific, organizational, and fiscal oversight of the Consortium for Development of Immunotherapeutics Against Viral Hemorrhagic Fevers. This consortium includes multiple investigators and a vast array of antibodies with in vitro or in vivo efficacy against the filoviruses and arenaviruses. An essential feature ofthe consortium is coordination of projects and studies on these antibodies, so that effort is not unduly duplicated, the separate multidisciplinary analyses integrate effectively and seamlessly, and the group achieves maximum synergy. The Administrative Core will develop and implement a management plan to ensure the success of this program. This Core will continuously monitor the scientific progress of each component of the program and ensure that results, the meaning of the results, and next steps are effectively communicated to the rest of the group at each stage. This Core will also facilitate communications with the NIH, the larger research community, and our external advisors so that these comprehensive studies are definitive and defined by consensus in the fields, and so that the resulting products can be effectively translated toward clinical use. The Core will manage financial resources and ensure that the select agent, vertebrate animal, human subject, and intellectual property issues are respected. The Core will also initiate all external collaborations and oversee invitation, selection, and progress of supplemental research activities as directed by the NIH.
This Core will provide the necessary administrative, organizational and fiscal oversight to ensure that critical antibody therapeutics against viral hemorrhagic fevers are translated toward patient use.
|Liu, Guodong; Wong, Gary; Su, Shuo et al. (2017) Clinical Evaluation of Ebola Virus Disease Therapeutics. Trends Mol Med 23:820-830|
|Wong, Gary; Mendoza, Emelissa J; Plummer, Francis A et al. (2017) From bench to almost bedside: the long road to a licensed Ebola virus vaccine. Expert Opin Biol Ther :1-15|
|Hofmann, Daniel; Lai, Jonathan R (2017) Exploring Human Antimicrobial Antibody Responses on a Single B Cell Level. Clin Vaccine Immunol 24:|
|Nyakatura, Elisabeth K; Soare, Alexandra Y; Lai, Jonathan R (2017) Bispecific antibodies for viral immunotherapy. Hum Vaccin Immunother 13:836-842|
|Zhao, Xuelian; Howell, Katie A; He, Shihua et al. (2017) Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability. Cell 169:891-904.e15|
|Mire, Chad E; Geisbert, Joan B; Borisevich, Viktoriya et al. (2017) Therapeutic treatment of Marburg and Ravn virus infection in nonhuman primates with a human monoclonal antibody. Sci Transl Med 9:|
|He, Jing; Melnik, Lilia I; Komin, Alexander et al. (2017) Ebola Virus Delta Peptide is a Viroporin. J Virol :|
|Fausther-Bovendo, H; Qiu, X; McCorrister, S et al. (2017) Ebola virus infection induces autoimmunity against dsDNA and HSP60. Sci Rep 7:42147|
|Wec, Anna Z; Herbert, Andrew S; Murin, Charles D et al. (2017) Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses. Cell 169:878-890.e15|
|Kroeker, Andrea; He, Shihua; de La Vega, Marc-Antoine et al. (2017) Characterization of Sudan Ebolavirus infection in ferrets. Oncotarget 8:46262-46272|
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