The primary objective of the Administrative Core is to provide the support structures for the management, coordination, and evaluation ofthe Center's activities. The Administrative Core will: ? Maintain a Scientific Advisory Committee whose members will review and recommend changes to the Center's strategic direction, assist Center leadership in making prioritization decisions, maintain institutional support and commitment, and ensure that the Center's programs are continually evaluated for their progress and potential to meet the strategic objectives of the CETR program. ? Work collaboratively with Principal Investigators to support their research efforts through the use of the Center's core laboratory, to identify collaborators whose joint efforts could synergistically benefit the collaborators'research programs, and to identify additional resources, including those provided by NIAID and other government agencies, that could contribute to a successful research and product development effort. ' ? Assist Principal Investigators to create a path from research towards product development. The core may engage consultants with specific expertise in product development to advise investigators on creating a developmental plan and identifying additional resources and expertise such as contract manufacturing and regulatory affairs. ? Ensure financial accountability for the Center's resources by the use of financial management systems appropriate to a center with multiple investigator-initiated research programs, core facilities, contract research, and a supplemental projects initiative. ? Monitor and ensure regulatory compliance with regard to general laboratory safety, biosafety select agent research, use and care of laboratory animals, and research involving human subjects. ? Monitor and evaluate the Center's research projects, core facilities, administrative systems, and funding of supplemental projects.
A well-coordinated and efficiently run and creative multi-project center depends on an effective Administrative operation to ensure that all components ofthe center are working together, exchanging ideas, and responding strategically to both research successes and roadblocks.
|Lorenz, Christian; Dougherty, Thomas J; Lory, Stephen (2016) Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway. J Bacteriol 198:3162-3175|
|Markovski, Monica; Bohrhunter, Jessica L; Lupoli, Tania J et al. (2016) Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity. Proc Natl Acad Sci U S A 113:4788-93|
|Rajagopal, Mithila; Martin, Melissa J; Santiago, Marina et al. (2016) Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries. MBio 7:|
|Simpson, Brent W; Owens, Tristan W; Orabella, Matthew J et al. (2016) Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function. MBio 7:|
|Matano, Leigh M; Morris, Heidi G; Wood, B McKay et al. (2016) Accelerating the discovery of antibacterial compounds using pathway-directed whole cell screening. Bioorg Med Chem 24:6307-6314|
|Meeske, Alexander J; Riley, Eammon P; Robins, William P et al. (2016) SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature 537:634-638|
|Pasquina, Lincoln; Santa Maria Jr, John P; McKay Wood, B et al. (2016) A synthetic lethal approach for compound and target identification in Staphylococcus aureus. Nat Chem Biol 12:40-5|
|Lee, Wonsik; Schaefer, Kaitlin; Qiao, Yuan et al. (2016) The Mechanism of Action of Lysobactin. J Am Chem Soc 138:100-3|
|Cho, Hongbaek; Wivagg, Carl N; Kapoor, Mrinal et al. (2016) Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously. Nat Microbiol :16172|
|Meeske, Alexander J; Rodrigues, Christopher D A; Brady, Jacqueline et al. (2016) High-Throughput Genetic Screens Identify a Large and Diverse Collection of New Sporulation Genes in Bacillus subtilis. PLoS Biol 14:e1002341|
Showing the most recent 10 out of 17 publications