The Specific Aims ofthe Enteric CETR Administrative Core will be to 1) manage, 2) coordinate, and 3) supervise the entire range of Center activities towards the primary goal of successful implementation of the Enteric CETR Strategic Plan. To that end, the Core will focus on effectively managing resources, facilitating communications amongst the project leaders and Principal Investigator, monitoring and reporting progress, and providing administrative and financial support to all Research Projects throughout the Center. The primary goal of the Enteric CETR Management team will be to maintain a functional, flexible, effective management structure for a complex, diverse, geographically dispersed, continually changing coalition with many intertwined goals and objectives. The Enteric CETR will be led by its Principal Investigator, Myron M. Levine, M.D., D.T.P.H., who will foster a strong collaborative environment and oversee coordination efforts among the five Research Projects and any future Supplemental Research Projects. He will be responsible for monitoring all research and overseeing the implementation of the Product Development Strategies. He will share his experience in enteric vaccine product development and provide guidance to each of the projects in this area. A Scientific Advisory Committee, Executive Committee and External Advisory Board (including a Regulatory Expert) will interact and support the PI in the overall management and evaluation of CETR research.

Public Health Relevance

We believe this CETR Administrative Core Management team will provide the infrastructure and leadership that will be central to the Center's success. This experienced team is prepared to manage, coordinate, and supervise the entire range of Center activities with the primary goal of successful implementation ofthe Strategic Plan of the Center.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-LR-M (J1))
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University of Maryland Baltimore
United States
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Sheoran, Abhineet S; Pina-Mimbela, Ruby; Keleher, Alison et al. (2018) Infection with anthroponotic Cryptosporidium parvum does not fully protect the host against a subsequent challenge with C. hominis. Microbes Infect 20:267-270
Higginson, Ellen E; Ramachandran, Girish; Hazen, Tracy H et al. (2018) Improving Our Understanding of Salmonella enterica Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain. mSphere 3:
Fuche, Fabien J; Sen, Sunil; Jones, Jennifer A et al. (2018) Characterization of Invasive Salmonella Serogroup C1 Infections in Mali. Am J Trop Med Hyg 98:589-594
Chen, Xinhua; Kelly, Ciaran P (2018) On and Off: A Dual Role for Cysteine Protease Autoprocessing of C difficile Toxin B on Cytotoxicity vs Proinflammatory Toxin Actions? Cell Mol Gastroenterol Hepatol 5:654-655
Zhang, Yongrong; Li, Shan; Yang, Zhiyong et al. (2018) Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity. Cell Mol Gastroenterol Hepatol 5:611-625
Bolick, D T; Medeiros, P H Q S; Ledwaba, S E et al. (2018) The Critical Role of Zinc in a New Murine Model of Enterotoxigenic E. coli (ETEC) Diarrhea. Infect Immun :
Zhou, Fenfen; Hamza, Therwa; Fleur, Ashley S et al. (2018) Mice with Inflammatory Bowel Disease are Susceptible to Clostridium difficile Infection With Severe Disease Outcomes. Inflamm Bowel Dis 24:573-582
Sztein, Marcelo B (2018) Is a Human CD8 T-Cell Vaccine Possible, and if So, What Would It Take? CD8 T-Cell-Mediated Protective Immunity and Vaccination against Enteric Bacteria. Cold Spring Harb Perspect Biol 10:
Yu, Hua; Chen, Kevin; Sun, Ying et al. (2017) Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity. Clin Vaccine Immunol 24:
Salerno-Gonçalves, Rosângela; Tettelin, Hervé; Lou, David et al. (2017) Use of a novel antigen expressing system to study the Salmonella enterica serovar Typhi protein recognition by T cells. PLoS Negl Trop Dis 11:e0005912

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