The administrative and quantitative core will provide scientific leadership and administrative coordination to the four research Projects and the Cores that support them. Raymond M. Welsh, PhD, the Principal Investigator of the Program Project, will serve as PI of this Administrative and Quantitative Core. He will be assisted by a Leadership Group, consisting of the senior Project leader, Susan Swain, PhD, and the senior Core leader, Lawrence Stern, PhD. An extended Advisory Committee will include the Leadership Group and senior UMMS advisors Kenneth Rock, MD and Leslie Berg, PhD, who are in our Department of Pathology but not investigators in this grant. This Core will support a partial salary for a secretary and for two statisticians, Bruce Barton, PhD, and Hua Fang, PhD. Core A will be responsible for 1. Oversight on program project budgets and business operations, including coordinating with and filing reports to the NIH;2. coordination of the services of the Cores with the needs of the Projects;3. organization of weekly program project meetings;4. coordination of visits of investigators outside of UMMS to come, give seminars, and consult with the PPG participants;5. provision of statistical expertise, consultation, and analyses;and 6. oversight ofthe PPG resource sharing plan.

Public Health Relevance

of Core A to the rest of the Program Project is to coordinate its activities, ensure smooth running interactions between the projects and the cores, arrange for scientific and statistical consultation, and to communicate with the NIH and comply with its regulations.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Research Program--Cooperative Agreements (U19)
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Special Emphasis Panel (ZAI1-ZL-I (J1))
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University of Massachusetts Medical School Worcester
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Urban, Stina L; Berg, Leslie J; Welsh, Raymond M (2016) Type 1 interferon licenses naïve CD8 T cells to mediate anti-viral cytotoxicity. Virology 493:52-9
Bautista, Bianca L; Devarajan, Priyadharshini; McKinstry, K Kai et al. (2016) Short-Lived Antigen Recognition but Not Viral Infection at a Defined Checkpoint Programs Effector CD4 T Cells To Become Protective Memory. J Immunol 197:3936-3949
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Stadinski, Brian D; Obst, Reinhard; Huseby, Eric S (2016) A "hotspot" for autoimmune T cells in type 1 diabetes. J Clin Invest 126:2040-2
Fonseca, Jairo Andres; Cabrera-Mora, Monica; Singh, Balwan et al. (2016) A chimeric protein-based malaria vaccine candidate induces robust T cell responses against Plasmodium vivax MSP119. Sci Rep 6:34527
Che, Jenny W; Daniels, Keith A; Selin, Liisa K et al. (2016) Heterologous immunity and persistent murine cytomegalovirus infection. J Virol :
Strutt, Tara M; McKinstry, Karl Kai; Kuang, Yi et al. (2016) Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza. J Immunol 197:3260-3270
Wyss, Lena; Stadinski, Brian D; King, Carolyn G et al. (2016) Affinity for self antigen selects Treg cells with distinct functional properties. Nat Immunol 17:1093-101
Devarajan, Priyadharshini; Bautista, Bianca; Vong, Allen M et al. (2016) New Insights into the Generation of CD4 Memory May Shape Future Vaccine Strategies for Influenza. Front Immunol 7:136

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