The Administrative Core will provide leadership for this U19 Cooperative Agreement on the immune response to orthopoxviruses. It will integrate and enhance the scientific activities of principal investigators at Washington University School of Medicine in St. Louis and at Oregon Heath and Sciences University in Portland.
The Specific Aims of the Administrative Core are to: 1. Coordinate and integrate U19 activities to expedite generation of outstanding research findings;2. Facilitate interaction among principal investigators with particular emphasis on programs to enhance sharing of preliminary data and reagents for collaboration; 3. Evaluate progress of U19 scientific work and prioritize as needed;4. Identify new research opportunities; and 5. Work with NIAID program officials to facilitate interactions with other U19's supported by RFA-AI-12- 048. Thus the Administrative Core will endeavor to expedite the generation of new research findings.
|Theisen, Derek J; Davidson 4th, Jesse T; Briseño, Carlos G et al. (2018) WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science 362:694-699|
|Loo, Christopher P; Nelson, Nicholas A; Lane, Ryan S et al. (2017) Lymphatic Vessels Balance Viral Dissemination and Immune Activation following Cutaneous Viral Infection. Cell Rep 20:3176-3187|
|Ghasemi, Reza; Lazear, Eric; Wang, Xiaoli et al. (2016) Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy. Nat Commun 7:12878|
|Gilchuk, Iuliia; Gilchuk, Pavlo; Sapparapu, Gopal et al. (2016) Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections. Cell 167:684-694.e9|
|Lubman, Olga Y; Fremont, Daved H (2016) Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors. Structure 24:57-69|
|Nelson, Christopher A; Epperson, Megan L; Singh, Sukrit et al. (2015) Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily. Viruses 7:4878-98|
|Nelson, Christopher A; Lee, Chung A; Fremont, Daved H (2014) Oxidative refolding from inclusion bodies. Methods Mol Biol 1140:145-57|
|Alzhanova, Dina; Hammarlund, Erika; Reed, Jason et al. (2014) T cell inactivation by poxviral B22 family proteins increases viral virulence. PLoS Pathog 10:e1004123|
|Nelson, Christopher A; McCoy, William H; Fremont, Daved H (2014) Eukaryotic expression systems for structural studies. Methods Mol Biol 1140:107-16|
|Luteijn, Rutger D; Hoelen, Hanneke; Kruse, Elisabeth et al. (2014) Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP. J Immunol 193:1578-89|