The lack of effective vaccines and therapeutic treatments for many viruses presents a heath concern of significant proportions. Host defenses against viruses require adaptive immune functions provided by both B cells and T cells, but the cellular and molecular processes that control the functions of these cells are incompletely understood. Although the persistence of viral antigens, the cytokine milieu in local microenvironments, the concentration and placement of immune cells in lymphoid and non-lymphoid organs, and the availability and type of costimulation can all dramatically affect the ultimate biological outcome of an immune response to virus infection or vaccination, it is unclear how these factors are controlled or how viruses manipulate each of these factors to evade or subvert immunity. These basic knowledge gaps limit our ability to rationally design new vaccines and to develop interventions to treat virus-mediated diseases. Therefore the overall goal of this U19 Program is to determine how various types of virus infections (chronic systemic, acute-systemic and acute-mucosal) affect the factors described above and lead to specific types of immune responses. In order to meet this goal, five labs with complementary expertise in human and mouse anti-viral immunology will work collaboratively to some of the key unresolved issues in anti-viral immunity. The major objectives of Core A are to provide administrative oversight and support for the program as a whole and for each of the individual projects, to provide biostatistics support for all the projects, to organize the external advisor visits, to organize yearly trips to the U19 conference and to organize monthly phone conferences and yearly face-to-face meetings of the investigators in each of the projects

Public Health Relevance

The lack of effective vaccines and therapeutic treatments for many viruses presents a heath concern of significant proportions. Thus the overall goal of this U19 Program is to determine how various types of virus infections affect specific types of immune responses. The major objectives of Core A are to provide administrative oversight and support, to provide biostatistics support, to organize the external advisor visits, to organize yearly trips to the U19 conference and to organize monthly phone conferences and yearly face to- face meetings of the investigators in each of the projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109962-01
Application #
8677092
Study Section
Special Emphasis Panel (ZAI1-ZL-I (J1))
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$98,633
Indirect Cost
$21,540
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Nguyen, Trang T T; Kläsener, Kathrin; Zürn, Christa et al. (2017) The IgM receptor Fc?R limits tonic BCR signaling by regulating expression of the IgM BCR. Nat Immunol 18:321-333
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Baumgarth, Nicole (2017) A Hard(y) Look at B-1 Cell Development and Function. J Immunol 199:3387-3394
Nellore, Anoma; Randall, Troy D (2016) Narcolepsy and influenza vaccination-the inappropriate awakening of immunity. Ann Transl Med 4:S29
Tian, Yuan; Cox, Maureen A; Kahan, Shannon M et al. (2016) A Context-Dependent Role for IL-21 in Modulating the Differentiation, Distribution, and Abundance of Effector and Memory CD8 T Cell Subsets. J Immunol 196:2153-66
Nguyen, Trang T T; Baumgarth, Nicole (2016) Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases. Crit Rev Immunol 36:163-177
Tian, Yuan; Mollo, Sarah B; Harrington, Laurie E et al. (2016) IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection. J Immunol 197:1308-21

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