Although studies in mice or non-human primates are often used to make conclusions about human disease, these species do not always respond in the same way. In fact, recent studies show that acute responses to various types of inflammation are very similar between humans of different genetic backgrounds, but poorly correlate with supposedly equivalent mouse models. Thus, human studies that validate the conclusions made from studies in other species are not only important, but are necessary to understand mechanisms of human disease. Moreover, coordinated animal and human studies allow investigators to learn from each model, develop new hypotheses and design better experiments that in mice, will further dissect mechanisms of disease and |n humans, will validate the conclusions drawn from animal studies, since complex mechanistic studies cannot be ethically proposed in human subjects. Therefore, the goal of the human immunology core will be to enable the performance of human studies that will test key hypotheses of each project proposed in the Ul9 program. To achieve this goal. Core C will recruit human subjects and collect clinical samples and clinical information, validate the antigen-specific B cell tetramers in human clinical samples and provide the clinical infrastructure and research expertise for the analysis of virus-specific B and T cells from human samples. The clinical core will coordinate all aspects of the studies related to direct patient contact and specimen collection for the Projects of the U19

Public Health Relevance

Core C: Human Immunology, will provide the clinical infrastructure, knowledge and expertise to recruit human subjects, collect samples from human subjects and perform experiments using those clinical samples that will directly advance the goals of each of the projects in the U19. -

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Program--Cooperative Agreements (U19)
Project #
1U19AI109962-01
Application #
8677096
Study Section
Special Emphasis Panel (ZAI1-ZL-I (J1))
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$366,384
Indirect Cost
$80,011
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Nguyen, Trang T T; Baumgarth, Nicole (2016) Natural IgM and the Development of B Cell-Mediated Autoimmune Diseases. Crit Rev Immunol 36:163-177
Tian, Yuan; Mollo, Sarah B; Harrington, Laurie E et al. (2016) IL-10 Regulates Memory T Cell Development and the Balance between Th1 and Follicular Th Cell Responses during an Acute Viral Infection. J Immunol 197:1308-21

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